EN2 and FOXA2

Number of citations: 0 (PubMedID 12642491)
Data Source: BioGRID (pull down), HPRD (in vitro)

		EN2	FOXA2
Name		engrailed homeobox 2	forkhead box A2
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Dopaminergic Neuron Differentiation Embryonic Brain Development	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Positive Regulation Of Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation
Pathways		None	Regulation of gene expression in beta cells Positive Regulation of CDH1 Gene Transcription Formation of axial mesoderm Formation of definitive endoderm Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs		N-cyclohexyltaurine	None
GWAS		Cytomegalovirus pp28 antibody levels ( 33204752 ) HDL cholesterol levels in HIV infection ( 33109212 ) Metabolite levels ( 23823483 )	Adolescent idiopathic scoliosis ( 25784220 ) Apolipoprotein A1 levels ( 32203549 ) Birth weight ( 31043758 ) Body size at age 10 ( 32376654 ) Fasting blood glucose ( 22581228 33842983 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting glucose ( 34059833 ) Fasting plasma glucose ( 20152958 25187374 ) Gout ( 22179738 ) Hypothyroidism ( 27182965 ) Male-pattern baldness ( 27182965 22693459 ) Monobrow ( 27182965 ) Type 2 diabetes ( 30054458 32499647 ) Vitamin D levels ( 26704534 )
Interacting Genes		2 interacting genes: EIF4E FOXA2	10 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTUD3 OTX2 TLE1
Entrez ID		2020	3170
HPRD ID		08836	02618
Ensembl ID		ENSG00000164778	ENSG00000125798
Uniprot IDs		P19622	B0ZTD4 Q9Y261
PDB IDs		Not available	5X07 7YZE 7YZF
GO Terms Enriched among Interactors		Eukaryotic Initiation Factor 4G Binding Neuron Differentiation MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse RNA Cap Binding RNA 7-methylguanosine Cap Binding Chromatoid Body Negative Regulation Of Cell Differentiation Eukaryotic Translation Initiation Factor 4F Complex Primitive Streak Formation Positive Regulation Of Gastrulation Regulation Of Gastrulation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Endocrine Pancreas Development Positive Regulation Of Embryonic Development Response To Interleukin-6 Negative Regulation Of Developmental Process Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Dopaminergic Neuron Differentiation Fear Response Response To Dexamethasone Negative Regulation Of Epithelial To Mesenchymal Transition Translation Initiation Factor Activity RNA Export From Nucleus Cell Cycle G1/S Phase Transition Cellular Response To Steroid Hormone Stimulus G1/S Transition Of Mitotic Cell Cycle Cytoplasmic Ribonucleoprotein Granule Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus MRNA Export From Nucleus Multicellular Organismal Response To Stress Translational Initiation Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Adult Locomotory Behavior Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Embryonic Development Cell Fate Specification RISC Complex Cytoplasmic Stress Granule	Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gastrulation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Primitive Streak Formation Regulation Of Gastrulation Neuron Differentiation DNA Binding Animal Organ Development Positive Regulation Of Embryonic Development Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Midbrain Development Dopaminergic Neuron Differentiation Endoderm Development Animal Organ Morphogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Gastrulation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cerebellum Development Regionalization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Tissue Development Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Dorsal Spinal Cord Interneuron Posterior Axon Guidance Nephric Duct Elongation Ectoderm Formation Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose