EN2 and FOXA2

Number of citations of the paper that reports this interaction (PMID 12642491)
13

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EN2	FOXA2
Gene Name		engrailed homeobox 2	forkhead box A2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Membrane	Nucleus Cytoplasm
	Molecular Function	Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Multicellular Organismal Development Midbrain Development Hindbrain Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose In Utero Embryonic Development Ectoderm Formation Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Adult Locomotory Behavior Negative Regulation Of Epithelial To Mesenchymal Transition Chromatin Modification Regulation Of Steroid Metabolic Process Cell Differentiation In Hindbrain Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Blood Coagulation Endocrine Pancreas Development Somite Rostral/caudal Axis Specification Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Development Neuron Fate Specification Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Connective Tissue Development Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways			Regulation of beta-cell development Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 20152958) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		1 interactors: FOXA2	9 interactors: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		2020	3170
HPRD ID		08836	02618
Ensembl ID		ENSG00000164778	ENSG00000125798
Uniprot IDs		P19622	B0ZTD4 Q9Y261
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Detection Of Glucose Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Transcription By Glucose Ectoderm Formation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription By Glucose Negative Regulation Of Glucokinase Activity Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Positive Regulation Of Gastrulation Positive Regulation Of Transcription From RNA Polymerase III Promoter Primitive Streak Formation Somite Rostral/caudal Axis Specification Dopaminergic Neuron Differentiation Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription From RNA Polymerase III Promoter Ectoderm Development Cell Differentiation In Hindbrain Neuron Fate Specification Positive Regulation Of Embryonic Development Response To Interleukin-6 Negative Regulation Of Stem Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Gastrulation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Dorsal/ventral Neural Tube Patterning Cellular Response To Nutrient Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Embryonic Axis Specification Endocrine Pancreas Development Gastrulation With Mouth Forming Second Regulation Of Epithelial To Mesenchymal Transition Lung Epithelial Cell Differentiation Neural Tube Patterning Lung Cell Differentiation Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Lung Morphogenesis Anterior/posterior Axis Specification Lung Epithelium Development Neuron Fate Commitment Somitogenesis Embryonic Pattern Specification Cell Fate Specification Regulation Of Smoothened Signaling Pathway Pancreas Development Regulation Of Steroid Metabolic Process Somite Development	Organ Development Positive Regulation Of Gene Expression System Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Hindbrain Development Embryonic Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Embryonic Morphogenesis Developmental Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Endoderm Development Embryonic Organ Morphogenesis Brain Development Chordate Embryonic Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Embryo Development Ending In Birth Or Egg Hatching Head Development Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Metencephalon Development Central Nervous System Development Somite Rostral/caudal Axis Specification Cell Development Forebrain Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Epithelium Development RNA Metabolic Process Embryonic Skeletal System Development Embryo Development Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Gastrulation
Tagcloud ?		administering afforded akt3 ameliorated asd autism autisms bckdk clues cntn5 cntnap2 cyfip1 fmr1 individually mecp2 neuroanatomical neuroligins neurorexins personalized pharmacologic phenotypically plausible polygenic scn1a shank2 siblings slc6a4 tailored tsc1	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Difference) ?		administering afforded akt3 ameliorated asd autism autisms bckdk clues cntn5 cntnap2 cyfip1 fmr1 individually mecp2 neuroanatomical neuroligins neurorexins personalized pharmacologic phenotypically plausible polygenic scn1a shank2 siblings slc6a4 tailored tsc1	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Intersection) ?