ZNF48 and TACC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF48	TACC1
Description		zinc finger protein 48	transforming acidic coiled-coil containing protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Midbody
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Nuclear Migration Cerebral Cortex Development Positive Regulation Of DNA-templated Transcription Cell Division
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Blond vs. brown/black hair color ( 30531825) Chronic mountain sickness ( 31417607) Midgestational circulating levels of PBDEs ( 28235828)
Interacting Genes		19 interacting genes: APOBEC3C BYSL CEP55 EIF3E FNDC11 GOLGA2 GOLGA6L9 HOOK2 MORF4L2 MTUS2 OGT OSBPL3 PRPF31 SF3B4 TACC1 TLE5 TRIM41 ZNF774 ZNF792	20 interacting genes: AURKA AURKB BTRC ERCC4 FAM50B HTT ITSN2 KAT2A KDM1A LSM7 MEMO1 SH2D4A SNRPG STX5 TDRD7 THAP12 THRA YEATS4 ZFHX3 ZNF48
Entrez ID		197407	6867
HPRD ID		15836	10391
Ensembl ID		ENSG00000180035	ENSG00000147526
Uniprot IDs		A0A087WVT1 Q96MX3	B7Z3G3 E5RFM9 E7ET87 E7EVI4 O75410
PDB IDs
Enriched GO Terms of Interacting Partners?			Spliceosomal Tri-snRNP Complex Chromosome Passenger Complex Nucleoplasm Nucleus Regulation Of DNA Metabolic Process Cellular Response To UV Regulation Of Microtubule-based Process U2-type Prespliceosome P Granule Cellular Response To Light Stimulus Microtubule Cytoskeleton Organization Involved In Mitosis U12-type Spliceosomal Complex Regulation Of Signal Transduction By P53 Class Mediator Spindle Midzone Protein Serine/threonine/tyrosine Kinase Activity Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Response To UV Cellular Response To Radiation Regulation Of Cell Division Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Regulation Of Protein Stability Peptide Glutaryltransferase Activity U4/U6 X U5 Tri-snRNP Complex Spindle Microtubule Mitotic Spindle Pole Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Nucleobase-containing Compound Metabolic Process Midbody Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Locomotor Rhythm Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Regulation Of Organelle Organization Regulation Of Centrosome Cycle Regulation Of DNA Repair Chromatin Organization Histone H3K9 Acetyltransferase Activity Protein Destabilization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity U2-type Precatalytic Spliceosome Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
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