EFNA3 and CD48

Data Source: HiPPIP (Novel)

		EFNA3	CD48
Name		ephrin A3	CD48 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Side Of Membrane	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	Protein Binding Receptor Ligand Activity
	Biological Process	Cell-cell Signaling Axon Guidance Negative Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Cell surface interactions at the vascular wall
GWAS		Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cataracts (operation) ( 31816047 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Optic disc size ( 31809533 ) Prostate cancer ( 23535732 ) Refractive error ( 32231278 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urinary albumin excretion ( 30220432 )	Blood protein levels ( 30072576 ) Inflammatory bowel disease ( 23128233 ) Itch intensity from mosquito bite ( 28199695 ) Multiple sclerosis ( 31604244 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Novel Interactors		1 novel interactors: CD48	10 novel interactors: ACKR1 DIO1 E2F2 EFNA1 EFNA3 KPLCE LY9 MAST2 OAZ3 P4HA1
Interacting Genes		11 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP1-1 KRTAP10-3 LCE2C MEOX2 NOTCH2NLA PRSS23	10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK
Entrez ID		1944	962
HPRD ID		03225	00177
Ensembl ID		ENSG00000143590	ENSG00000117091
Uniprot IDs		P52797	A0A087X1S7 P09326
PDB IDs		Not available	2EDO
GO Terms Enriched among Interactors		Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Transmembrane-ephrin Receptor Activity Protein Tyrosine Kinase Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Regulation Of GTPase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Nephric Duct Morphogenesis Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Axonal Fasciculation Neuron Projection Fasciculation Ephrin Receptor Binding Dendrite Neuron Projection Development Growth Factor Binding Regulation Of Catalytic Activity Neuron Recognition Notochord Cell Development DH Domain Binding Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Plasma Membrane Tube Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Morphogenesis Of An Epithelium Axial Mesoderm Formation Neuromuscular Junction Positive Regulation Of Protein Localization To Membrane ATP Binding Regulation Of Cell Adhesion Keratin Filament Negative Regulation Of Lymphangiogenesis Notochord Formation Schaffer Collateral - CA1 Synapse Plasma Membrane Bounded Cell Projection Organization Postsynaptic Density Membrane Tissue Morphogenesis Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Blood Vessel Endothelial Cell Migration	Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process