TFDP2 and E2F4

Number of citations of the paper that reports this interaction (PMID 10090723)
69

Data Source:
HPRD (in vitro)

		TFDP2	E2F4
Gene Name		transcription factor Dp-2 (E2F dimerization partner 2)	E2F transcription factor 4, p107/p130-binding
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleoplasm Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Factor Binding Protein Domain Specific Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Epithelial Cell Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Volume Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Cell Size Organ Morphogenesis Gene Expression Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Pre-NOTCH Transcription and Translation Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146)
Protein-Protein Interactions		6 interactors: E2F1 E2F2 E2F3 E2F4 E2F6 YWHAE	25 interactors: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A FHL2 HCFC1 ID3 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		7029	1874
HPRD ID		03696	02806
Ensembl ID		ENSG00000114126	ENSG00000205250
Uniprot IDs		Q14188	Q16254
PDB IDs		1CF7	1CF7
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Lens Fiber Cell Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Transcription, DNA-templated Cell Cycle Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator RNA Biosynthetic Process Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization RNA Metabolic Process Signal Transduction By P53 Class Mediator Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone Notch Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Apoptotic Process Nucleobase-containing Compound Metabolic Process Programmed Cell Death Negative Regulation Of Protein Dephosphorylation Multi-ciliated Epithelial Cell Differentiation Positive Regulation Of Intracellular Transport Cell Death Death Anoikis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Cycle Process Regulation Of Centrosome Duplication Androgen Receptor Signaling Pathway Regulation Of Centrosome Cycle Negative Regulation Of Centriole Replication
Tagcloud ?		accumulate causing cofactor cofactors coregulators coupling databases e2f2 elucidating erythrocyte erythroid erythropoiesis gata gata1 global globally highlight lymphocytic modulations pairs pinpoint promoters proper resource tal1 upregulate utilizing validate	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Difference) ?		accumulate causing cofactor cofactors coregulators coupling databases e2f2 elucidating erythrocyte erythroid erythropoiesis gata gata1 global globally highlight lymphocytic modulations pairs pinpoint promoters proper resource tal1 upregulate utilizing validate	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Intersection) ?