DMP1 and CFH

Number of citations of the paper that reports this interaction (PMID 11825898)
20

Data Source:
HPRD (in vitro)

		DMP1	CFH
Gene Name		dentin matrix acidic phosphoprotein 1	complement factor H
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Nucleus Nucleoplasm Nucleolus Cytoplasm Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Integrin Binding Calcium Ion Binding Extracellular Matrix Binding	Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Ossification Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Biomineral Tissue Development	Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response
Pathways		ECM proteoglycans	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Protein-Protein Interactions		2 interactors: CD44 CFH	16 interactors: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16
Entrez ID		1758	3075
HPRD ID		02989	00601
Ensembl ID		ENSG00000152592	ENSG00000000971
Uniprot IDs		Q13316	F8WDX4 P08603
PDB IDs			1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Monocyte Aggregation Monocyte Aggregation Regulation Of Protein Processing Wound Healing Involved In Inflammatory Response Positive Regulation Of Heterotypic Cell-cell Adhesion Complement Activation, Alternative Pathway Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Hyaluronan Catabolic Process Innate Immune Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Branching Involved In Prostate Gland Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Complement Activation Immune Response Defense Response Prostate Gland Epithelium Morphogenesis Hyaluronan Metabolic Process Prostate Gland Morphogenesis Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Humoral Immune Response Glycosaminoglycan Catabolic Process Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Prostate Gland Development Regulation Of Acute Inflammatory Response Positive Regulation Of Peptidyl-serine Phosphorylation Nephron Morphogenesis Renal Tubule Morphogenesis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Extracellular Matrix Disassembly Renal Tubule Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Immune System Process Kidney Morphogenesis Regulation Of Protein Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Interferon-gamma-mediated Signaling Pathway Mesonephros Development Regulation Of Response To DNA Damage Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Complement Activation Nephron Development	Immune System Process Immune Response Regulation Of Immune System Process Tissue Development Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Wounding Positive Regulation Of Reactive Oxygen Species Metabolic Process Defense Response Positive Regulation Of Cellular Metabolic Process Response To Hypoxia Response To Stress Wound Healing Complement Activation Positive Regulation Of Immune Response Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Organ Development Protein Activation Cascade Inflammatory Response Response To External Stimulus System Development Innate Immune Response Positive Regulation Of Metabolic Process Humoral Immune Response Response To Organic Cyclic Compound Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytokine Production Opsonization Phagocytosis Regulation Of Body Fluid Levels Organ Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cytokine Production Complement Activation, Classical Pathway
Tagcloud ?		7q21 adenosquamous alternatively deleted deposits diminishing dmp1alpha dmp1beta dmp1gamma haplo hemizygously hyperplasia indeed insufficient keratinized locus mmtv multifocal publicly seq spliced splicing surrounding transdifferentiation tumour tumourigenic tumours undefined upregulating	bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow
Tagcloud (Difference) ?		7q21 adenosquamous alternatively deleted deposits diminishing dmp1alpha dmp1beta dmp1gamma haplo hemizygously hyperplasia indeed insufficient keratinized locus mmtv multifocal publicly seq spliced splicing surrounding transdifferentiation tumour tumourigenic tumours undefined upregulating	bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow
Tagcloud (Intersection) ?