DMP1

Description		dentin matrix acidic phosphoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Integrin Binding Calcium Ion Binding Extracellular Matrix Binding
	Biological Process	Ossification Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Biomineral Tissue Development Regulation Of Enamel Mineralization
Pathways		ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Hypophosphatemic rickets; X-Linked dominant hypophosphatemia (XLH); Autosomal dominant hypophosphatemic rickets (ADHR); Autosomal recessive hypophosphatemic rickets (ARHR); Hereditary hypophophatemic rickets with hypercalciuria (HHRH)
GWAS		Dental caries ( 23064961) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		2 interacting genes: CD44 CFH
Entrez ID		1758
HPRD ID		02989
Ensembl ID		ENSG00000152592
Uniprot IDs		Q13316
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Monocyte Aggregation Macrophage Migration Inhibitory Factor Receptor Complex Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Hyaluronic Acid Binding Positive Regulation Of Heterotypic Cell-cell Adhesion Lamellipodium Membrane Leukocyte Aggregation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Glycosaminoglycan Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Hyaluronan Catabolic Process Hyaluronan Metabolic Process Serine-type Endopeptidase Complex Regulation Of Complement Activation, Alternative Pathway Heparan Sulfate Proteoglycan Binding Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity Symbiont Cell Surface Complement Component C3b Binding Wound Healing, Spreading Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Fibroblast Growth Factor Negative Regulation Of Signal Transduction By P53 Class Mediator Glycosaminoglycan Metabolic Process Cytokine Receptor Activity Regulation Of Humoral Immune Response Regulation Of Lamellipodium Organization Defense Response Complement Activation Leukocyte Cell-cell Adhesion Collagen Binding Microvillus Secretory Granule Membrane Cartilage Development Immune System Process Cell-matrix Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extracellular Exosome Regulation Of Signal Transduction By P53 Class Mediator Blood Microparticle Extracellular Region
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