TCEANC and IKZF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCEANC	IKZF2
Description		transcription elongation factor A N-terminal and central domain containing	IKAROS family zinc finger 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			C-reactive protein levels ( 30388399) Eosinophil count ( 19198610 32888494 27863252 29403010) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31451708) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Selective IgA deficiency ( 27723758) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systemic sclerosis ( 29293537) Type 2 diabetes ( 32499647)
Interacting Genes		140 interacting genes: ADARB1 AKAP9 ANAPC11 APP ATXN1 AXIN2 BICD2 BRCA1 C1QTNF2 C8orf34 CARD9 CBY2 CCDC102B CCDC136 CCDC138 CCDC33 CCDC85B CCNC CDR2L CEP70 CEP76 CRACR2B CREB3L3 CSRNP1 CTAG1A CTAG1B CYSRT1 DAB1 DISC1 DMAP1 DTX3 DVL3 DYNLT1 EVI5 FAM217B FAM9B FANCG FBXO25 FCHO1 FSD2 GOLGA2 GOLGA6L9 HES7 HIP1 HMBOX1 HOMEZ HOOK2 IGF1 IKBKG IKZF2 IKZF3 KATNBL1 KCTD6 KCTD7 KIAA1958 KIF16B KIFC3 KLHL12 KRT31 KRT35 KRT40 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP4-2 KRTAP5-9 L3MBTL3 LDOC1 LHX2 LHX3 LIN7B LMNA LSM14B LURAP1 MAGEA11 MCC MCIDAS MDFI MEOX1 MEOX2 MID1 MID2 MTUS2 MYF5 MYLIP NAB2 NECAB1 NEDD4 NINL OBI1 OOEP OSBPL3 PICK1 PLEKHF2 PNMA1 PNMA5 PXN RAD54B RNF41 RUBCN SIPA1L2 SORBS3 SSNA1 STRN3 STX1A STX4 TARBP2 TCP10L THAP1 TLE5 TMCO2 TNIP1 TNIP3 TRAF2 TRIM23 TRIM27 TRIM32 TRIM35 TRIM37 TRIM41 TRIM54 UBXN11 USH1G USHBP1 VAC14 VBP1 VPS52 YWHAE ZBTB14 ZBTB39 ZBTB9 ZFYVE26 ZKSCAN7 ZNF276 ZNF655 ZNF670 ZNF688 ZNF837 ZRANB1	10 interacting genes: AQP1 CFTR CTBP1 CTBP2 HDAC4 IKZF1 IKZF4 IKZF5 LONRF1 TCEANC
Entrez ID		170082	22807
HPRD ID		19501	05872
Ensembl ID		ENSG00000176896	ENSG00000030419
Uniprot IDs		A8K5F6 B4DG85 Q8N8B7	B4DWF2 Q9UKS7
PDB IDs			7LPS 8DEY
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Intermediate Filament Post-translational Protein Modification Ubiquitin-protein Transferase Activity Keratin Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Regulation Of Transcription By RNA Polymerase II Microtubule-based Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Zinc Ion Binding Suppression Of Viral Release By Host Regulation Of Viral Transcription Regulation Of Primary Metabolic Process Centrosome Cytoplasm Microtubule Binding Protein Monoubiquitination Regulation Of Organelle Organization Microtubule Regulation Of Cellular Component Organization Regulation Of Macromolecule Metabolic Process Protein Autoubiquitination Negative Regulation Of Viral Transcription Microtubule Cytoskeleton Organization Protein K63-linked Ubiquitination Nucleus Regulation Of Cytoskeleton Organization Enzyme Binding Signaling Adaptor Activity Protein Polyubiquitination Regulation Of Metabolic Process Intracellular Transport Somite Specification Response To Muramyl Dipeptide Establishment Of Localization In Cell Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process	Transepithelial Water Transport Protein Domain Specific Binding Transcription Repressor Complex Epithelial Fluid Transport Negative Regulation Of DNA-templated Transcription White Fat Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Viral Genome Replication Negative Regulation Of RNA Metabolic Process Water Transport Multicellular Organismal-level Water Homeostasis Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Fluid Transport Transepithelial Transport NAD Binding Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Binding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Cellular Response To CAMP Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Corepressor Binding Multicellular Organismal-level Chemical Homeostasis Protein-containing Complex Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Positive Regulation Of Anion Channel Activity Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To CAMP Positive Regulation Of Saliva Secretion Odontogenesis Cellular Response To Mercury Ion Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Monoatomic Anion Transport Axonemal Central Apparatus Regulation Of RNA Metabolic Process Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Hydrogen Peroxide Transmembrane Transport
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