DAW1 and RAB25

		DAW1	RAB25
Description		dynein assembly factor with WD repeats 1	RAB25, member RAS oncogene family
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Cilium SCF Ubiquitin Ligase Complex Motile Cilium Ciliary Basal Body Cell Projection	Golgi Apparatus Plasma Membrane Membrane Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Cell Projection Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding
	Biological Process	Protein Polyubiquitination Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Heart Development Outer Dynein Arm Assembly Intraciliary Transport Establishment Of Localization In Cell Axonemal Dynein Complex Assembly Cerebrospinal Fluid Circulation	Epithelial Cell Morphogenesis Exocytosis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Migration Protein Transport Pseudopodium Organization Regulation Of Vesicle-mediated Transport
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31959851 34103634)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Parkinson's disease ( 32201043)
Interacting Genes		2 interacting genes: SRPK1 SRPK2	14 interacting genes: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SH3BP5L SMAD4 SMURF2 TGFBR1
Entrez ID		164781	57111
HPRD ID		08079	06698
Ensembl ID		ENSG00000123977	ENSG00000132698
Uniprot IDs		A0A140VKH6 B4DX89 Q8N136	P57735
PDB IDs		5NNZ	2OIL 3TSO
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Regulation Of Viral Life Cycle Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of Viral Process Pseudopodium Membrane Regulation Of RNA Splicing Pseudopodium Organization Magnesium Ion Binding Protein-RNA Complex Assembly Nuclear Speck Organization Nucleotide Binding Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity RNA Splicing Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity R-loop Processing Nuclear Speck MRNA Processing Protein Kinase Activity Myosin V Binding Pseudopodium Nuclear Body Organization Sperm DNA Condensation MRNA Metabolic Process Kinase Activity Innate Immune Response Chromosome Defense Response To Other Organism Defense Response To Symbiont 14-3-3 Protein Binding Epithelial Cell Morphogenesis Chromatin Organization RNA Processing Peptidyl-serine Phosphorylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Migration Chromatin Response To Other Organism Positive Regulation Of Neuron Apoptotic Process Regulation Of Epithelial Cell Migration G Protein Activity Immune Response	SMAD Binding Recycling Endosome Negative Regulation Of Adiponectin Secretion Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Endosome Recycling Endosome Membrane Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Small GTPase Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Pattern Specification Process BMP Receptor Activity Positive Regulation Of Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Vesicle-mediated Transport Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Negative Regulation Of Protein Secretion Activin Binding BMP Signaling Pathway In Utero Embryonic Development Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chordate Embryonic Development Regulation Of Hormone Secretion Regulation Of Hormone Levels Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Cellular Response To Growth Factor Stimulus I-SMAD Binding Gastrulation With Mouth Forming Second Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulated Exocytosis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Pharyngeal System Development Regulation Of Signaling
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