ECI1 and MAPKAP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ECI1	MAPKAP1
Gene Name		enoyl-CoA delta isomerase 1	mitogen-activated protein kinase associated protein 1
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Dodecenoyl-CoA Delta-isomerase Activity Intramolecular Oxidoreductase Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Ras GTPase Binding Protein Kinase Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Fatty Acid Beta-oxidation Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Substantia Nigra Development T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Mitochondrial Fatty Acid Beta-Oxidation	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Octanoyl-Coenzyme A Benzamidine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP MAPKAP1 POT1	8 interactors: ABCB1 AKT1S1 CDC42EP1 ECI1 EIF4EBP1 MAPK8 PRR5L YWHAG
Entrez ID		1632	79109
HPRD ID		02628	17464
Ensembl ID		ENSG00000167969	ENSG00000119487
Uniprot IDs		P42126 Q96DC0	Q9BPZ7
PDB IDs		1SG4	3VOQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Strand Elongation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Telomere Formation Via Telomerase Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Axon Choice Point Recognition Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Neuron Remodeling Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Cellular Copper Ion Homeostasis Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Copper Ion Homeostasis Suckling Behavior Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Brain Development Negative Regulation Of Catalytic Activity Head Development Innate Immune Response Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Telomere Maintenance Via Telomere Lengthening Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Substantia Nigra Development Central Nervous System Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of DNA Replication	Intracellular Signal Transduction TOR Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Regulation Of Mitochondrion Organization TORC2 Signaling G2/M Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Regulation Of Signaling Mitotic Cell Cycle IRES-dependent Translational Initiation Cap-independent Translational Initiation JUN Phosphorylation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Xenobiotic Transport Positive Regulation Of Deacetylase Activity Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Signaling Negative Regulation Of Cellular Metabolic Process Response To Stimulus Cytoplasmic Translational Initiation Fc Receptor Signaling Pathway Cell Communication Cell Cycle Process
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