ACSL5 and SLC7A14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACSL5	SLC7A14
Description		acyl-CoA synthetase long chain family member 5	solute carrier family 7 member 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Nucleoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Arachidonate-CoA Ligase Activity Oleoyl-CoA Ligase Activity	Protein Binding Amino Acid Transmembrane Transporter Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Positive Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Extrinsic Apoptotic Signaling Pathway	Amino Acid Transmembrane Transport Amino Acid Transport Gamma-aminobutyric Acid Import Transmembrane Transport
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 32968195) Basophil percentage of white cells ( 32888494) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494)	Obesity (extreme) ( 30677029) Spontaneous preterm birth without premature rupture of membranes ( 31194736)
Interacting Genes		13 interacting genes: AQP6 CREB3 EBAG9 FBXO7 PEX12 RETREG3 SELENOI SLC10A1 SLC10A6 SLC16A7 SLC35H1 SLC7A14 TMEM14B	47 interacting genes: ACSL5 ADGRE2 AGTRAP AIG1 APOL3 BET1 BNIP1 BNIP2 C1GALT1 CBLIF CCDC167 CCL4L2 CD53 CMTM5 DCBLD2 DERL1 EOGT ERMP1 FAM209A FAM20B FATE1 FCER1G FKBP7 IL10RA LINC00839 LTC4S MFF MGLL MMGT1 NINJ2 NSG1 PLPP6 PRB1 SCARF1 SCD SMCO4 TECR TMEM128 TMEM31 TRARG1 TREX1 UBIAD1 VAMP2 VKORC1 YIPF4 YIPF6 ZFPL1
Entrez ID		51703	57709
HPRD ID		16139	17222
Ensembl ID		ENSG00000197142	ENSG00000013293
Uniprot IDs		A0A8C8L3F5 Q9ULC5	Q8TBB6
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Bile Acid:sodium Symporter Activity Organic Anion Transport Carboxylic Acid Transport Organic Acid Transport Symporter Activity Membrane Bile Acid And Bile Salt Transport Monocarboxylic Acid Transport Organic Hydroxy Compound Transport Nitrate Transmembrane Transporter Activity Pyruvate Secondary Active Transmembrane Transporter Activity Positive Regulation Of Deacetylase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Autophagy Secondary Active Monocarboxylate Transmembrane Transporter Activity Peroxisomal Importomer Complex Adaptive Immune Memory Response Involving T Cells And B Cells Lewy Body Core UDP-glucose Transmembrane Transport Ethanolaminephosphotransferase Activity Adaptive Immune Memory Response Pyruvate Transmembrane Transporter Activity Endoplasmic Reticulum-autophagosome Adaptor Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Peptidase Activator Activity Involved In Apoptotic Process Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Release From Viral Latency Protein O-linked Glycosylation Via Fucose Protein Import Into Peroxisome Matrix, Substrate Release Lactate Transmembrane Transporter Activity Pyruvate Transport CCR1 Chemokine Receptor Binding Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Fusion SNAP Receptor Activity Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Vesicle Fusion Vesicle Fusion With Golgi Apparatus Cobalt Ion Transport SNARE Complex Nuclear Envelope Fatty Acid Biosynthetic Process Intestinal Epithelial Cell Development Response To Oxygen-glucose Deprivation Establishment Of Protein Localization To Plasma Membrane Vitamin K Metabolic Process Endosome To Plasma Membrane Protein Transport Endomembrane System Columnar/cuboidal Epithelial Cell Development Golgi Vesicle Transport
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