CD55 and VPS26C

		CD55	VPS26C
Description		CD55 molecule (Cromer blood group)	VPS26 endosomal protein sorting factor C
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Plasma Membrane Cell Surface Membrane Transport Vesicle Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Extracellular Exosome Side Of Membrane Ficolin-1-rich Granule Membrane	Nucleus Endosome
	Molecular Function	Virus Receptor Activity Protein Binding Lipid Binding	Protein Binding
	Biological Process	Immune System Process Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Symbiont Entry Into Host Cell Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Intracellular Protein Transport Endocytic Recycling
Pathways		Class B/2 (Secretin family receptors) Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs		Chloramphenicol
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		6 interacting genes: ADGRE5 CD14 CR1 FYN GPLD1 LCK	44 interacting genes: AGTPBP1 ARHGAP21 ASH1L CBLB CCDC85A CIPC DCLK1 DDIT4L DECR2 DNAJB2 EPHB6 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PMS2 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 SETMAR TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655
Entrez ID		1604	10311
HPRD ID		00500	10390
Ensembl ID		ENSG00000196352	ENSG00000157538
Uniprot IDs		B1AP13 P08174	A8MTY9 A8MY26 O14972
PDB IDs		1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24 5FOA 6ILJ 6ILK 6LA5 7C9W 7DO4 7VY5 7VY6 8B8R 8K9R 8K9T	8P0X 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Positive Regulation Of Immune Response CD4 Receptor Binding Secretory Granule Membrane Phospholipase Activator Activity T Cell Receptor Binding Complement Receptor Mediated Signaling Pathway Regulation Of Immune Response Phosphatidylinositol 3-kinase Binding ATP Transport Positive Regulation Of Immune System Process Immune System Process Phospholipase Binding Cell Surface Receptor Signaling Pathway Membrane Raft Adenine Nucleotide Transport Purine Nucleotide Transport Fc-gamma Receptor Signaling Pathway Nucleotide Transport Regulation Of Regulatory T Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Response To Xenobiotic Stimulus Regulation Of Immune System Process Fc Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Opsonin Receptor Activity Complement Component C3b Receptor Activity Positive Regulation Of Lymphocyte Activation Immune Complex Clearance By Erythrocytes Positive Regulation Of Cell-cell Adhesion Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Carbohydrate Derivative Transport
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