USP54 and SAMD8

		USP54	SAMD8
Description		ubiquitin specific peptidase 54	sterile alpha motif domain containing 8
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GO Annotations	Cellular Component		Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity	Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity
	Biological Process	Proteolysis Protein Deubiquitination	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		89 interacting genes: ANKRD11 ANKS1A ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C CSTF2 CYSRT1 DMRT3 DOK6 DTX2 DYRK1A EIF4E2 EPM2AIP1 EXOC8 FAM124B FBXO17 FNDC3B FOXI1 GCM2 HGS HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76	1 interacting genes: TGFBR1
Entrez ID		159195	142891
HPRD ID		15641	18014
Ensembl ID		ENSG00000166348	ENSG00000156671
Uniprot IDs		A0A7P0T9K1 B7Z7X1 Q70EL1	Q96LT4 V9HVY4
PDB IDs		8C61	8IJQ 8IJR 8W9W 8W9Y
Enriched GO Terms of Interacting Partners?		Membrane Fission ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Membrane Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Multivesicular Body Assembly Lysosomal Membrane Organization Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Mitotic Metaphase Chromosome Alignment Endosome Organization Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Protein Binding Metaphase Chromosome Alignment Plasma Membrane Repair ESCRT III Complex Disassembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Release From Host Cell ESCRT Complex Disassembly Regulation Of Spindle Assembly Regulation Of Transcription By RNA Polymerase II Cytokinetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Spindle Organization Chromosome Localization Regulation Of Macromolecule Biosynthetic Process Multivesicular Body Regulation Of RNA Metabolic Process POZ Domain Binding Regulation Of Centrosome Duplication Nuclear Membrane Organization Regulation Of Primary Metabolic Process Autophagosome Maturation Autophagosome Membrane Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Ventricular Compact Myocardium Morphogenesis Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Extracellular Matrix Assembly Vascular Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Activity Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endothelial Cell Activation Transforming Growth Factor Beta Receptor Activity, Type I Transforming Growth Factor Beta Ligand-receptor Complex G1 To G0 Transition Involved In Cell Differentiation Coronary Vasculature Morphogenesis Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Ventricular Trabecula Myocardium Morphogenesis G1 To G0 Transition I-SMAD Binding K63-linked Deubiquitinase Activity Pharyngeal System Development Heart Trabecula Morphogenesis Transforming Growth Factor Beta Binding Serine/threonine Protein Kinase Complex Regulation Of Extracellular Matrix Assembly Filopodium Assembly Negative Regulation Of Cell Population Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Extracellular Matrix Organization Response To Cholesterol Positive Regulation Of Filopodium Assembly Cell Population Proliferation Negative Regulation Of Chondrocyte Differentiation Blastocyst Development Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cartilage Development Endothelial Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation
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