CYBA and NCF1

Number of citations of the paper that reports this interaction (PMID 12056906)
86

Data Source:
BioGRID (pull down, pull down)

		CYBA	NCF1
Gene Name		cytochrome b-245, alpha polypeptide	neutrophil cytosolic factor 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endosome Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane NADPH Oxidase Complex Neuronal Cell Body Perinuclear Endoplasmic Reticulum	Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Smooth Muscle Hypertrophy Cytochrome Complex Assembly Positive Regulation Of Cell Growth Response To Nutrient Levels Response To Drug Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interaction With Host Oxidation-reduction Process Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Gamma Radiation Phagosome Maturation	Response To Yeast Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Apoptotic Process Inflammatory Response Cellular Defense Response Cell Proliferation Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Negative Regulation Of Smooth Muscle Contraction Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Interaction With Host Oxidation-reduction Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Phagosome Maturation
Pathways		Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2	23 interactors: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PRKCA PRKCB PRKCD PRKCZ PRKDC SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		1535	653361
HPRD ID		01989
Ensembl ID		ENSG00000051523	ENSG00000158517
Uniprot IDs		B4DT46 P13498	P14598
PDB IDs		1WLP	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?		Respiratory Burst Superoxide Anion Generation Vascular Endothelial Growth Factor Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Superoxide Metabolic Process Phagosome Maturation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Interaction With Host Antigen Processing And Presentation Reactive Oxygen Species Metabolic Process Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Hyperoxia Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response Defense Response Immune System Process Cellular Defense Response Innate Immune Response Response To Stress Oxidation-reduction Process Cellular Stress Response To Acidic PH Positive Regulation Of Phosphorylation Cellular Response To Stimulus Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Signal Transduction Metabolic Process Oxygen Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Engulfment Of Apoptotic Cell Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Response To Drug Signaling Mast Cell Chemotaxis Regulation Of Integrin Biosynthetic Process Positive Regulation Of Stress-activated MAPK Cascade	Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3-T6 Phosphorylation Platelet Activation Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Immune Response Apoptotic Signaling Pathway Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Phospholipase Activity Cell Death Regulation Of Protein Phosphorylation Death Blood Coagulation Regulation Of Cellular Protein Metabolic Process Hemostasis Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Organelle Organization Mitotic Cell Cycle Positive Regulation Of Lipase Activity Response To Interleukin-1 Innate Immune Response Regulation Of Glucose Transport Regulation Of Platelet Aggregation Regulation Of Protein Metabolic Process Muscle System Process Negative Regulation Of Glucose Transport Signaling Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation
Tagcloud ?		anion besides biopsies chl copy cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf2 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Difference) ?		anion besides biopsies chl copy cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf2 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Intersection) ?		ncf1