CNTN4 and PRICKLE4

		CNTN4	PRICKLE4
Description		contactin 4	prickle planar cell polarity protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Axon Synapse Side Of Membrane	Stress Fiber Nucleus Adherens Junction Z Disc Filamentous Actin
	Molecular Function	Cell-cell Adhesion Mediator Activity	Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Brain Development Neuron Projection Development Negative Regulation Of Neuron Differentiation Regulation Of Synaptic Plasticity Synapse Organization Dendrite Self-avoidance	Heart Development Actin Cytoskeleton Organization Muscle Structure Development
Pathways		Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Amyotrophic lateral sclerosis ( 19451621) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atypical femoral fracture in phosphonate treatment ( 31006051) Autism spectrum disorder or schizophrenia ( 28540026) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood pressure ( 17903302) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Brain connectivity ( 23471985) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime sleep phenotypes ( 27126917) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration ( 29346644) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density x serum urate levels interaction ( 34046847) High density lipoprotein cholesterol levels ( 31647587 34074324) High myopia ( 32428537) Intake of total sugars ( 31005972) Intelligence ( 22449649) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016) Night sleep phenotypes ( 27126917) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to aripiprazole in schizophrenia ( 29503163) Restless legs syndrome ( 29029846) Schizophrenia ( 29483656 25056061 26198764 30285260 28991256) Sensorimotor dexterity ( 31596458) Serum immune biomarker levels ( 32066700) Serum uric acid levels ( 24379826) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Total ventricular volume ( 21116278) White blood cell count (basophil) ( 27863252)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: BARD1 BRCA1 BTG3	9 interacting genes: AGXT GNE HOXA1 MTDH NEK6 OTX1 PLEKHN1 ZNF417 ZNF587
Entrez ID		152330	29964
HPRD ID		16239	12884
Ensembl ID		ENSG00000144619	ENSG00000278224
Uniprot IDs		Q8IWV2	Q2TBC4
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Negative Regulation Of Mitotic Cell Cycle Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of MRNA 3'-end Processing Tubulin Binding Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Ubiquitin Ligase Complex Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Response To Ionizing Radiation Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cellular Response To Indole-3-methanol Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Negative Regulation Of Mitotic Cell Cycle Phase Transition	Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metencephalon Development CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process
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