CTSW and RICTOR

		CTSW	RICTOR
Description		cathepsin W	RPTOR independent companion of MTOR complex 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endoplasmic Reticulum Endomembrane System Membrane Platelet Dense Granule Lumen Intracellular Organelle Lumen	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane TORC2 Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Enzyme-substrate Adaptor Activity
	Biological Process	Immune System Process Proteolysis Immune Response Proteolysis Involved In Protein Catabolic Process	Positive Regulation Of Endothelial Cell Proliferation Cytoskeleton Organization Lipid Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Establishment Of Cell Polarity
Pathways		Platelet degranulation	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Inflammatory bowel disease ( 23128233) Monocyte count ( 32888494)	Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes		1 interacting genes: CREB3	11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB MTOR PLK1 SGK1 SIRT1 USP9X
Entrez ID		1521	253260
HPRD ID		03840	10682
Ensembl ID		ENSG00000172543	ENSG00000164327
Uniprot IDs		P56202	A0AA34QVX7 D6R9S6 Q6R327
PDB IDs			5ZCS 6ZWM 6ZWO 7PE7 7PE8 7PE9 7TZO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deacetylase Activity Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Release From Viral Latency Cholesterol Storage Sterol Binding Regulation Of Isoprenoid Metabolic Process Regulation Of Cell Growth Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Locomotion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Growth Positive Regulation Of Cell Motility Induction Of Positive Chemotaxis CAMP Response Element Binding Protein Binding Positive Regulation Of Positive Chemotaxis Cholesterol Transfer Activity Intracellular Sterol Transport Glycolipid Transport Intracellular Cholesterol Transport Lysosome TORC2 Complex Enzyme-substrate Adaptor Activity TORC2 Signaling Regulation Of Establishment Of Cell Polarity Negative Regulation Of CGAS/STING Signaling Pathway Serine/threonine Protein Kinase Complex Regulation Of Establishment Or Maintenance Of Cell Polarity CGAS/STING Signaling Pathway Cholesterol Efflux Negative Regulation Of Intracellular Signal Transduction Regulation Of Monocyte Chemotaxis Lipid Storage Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Lipid Transport Transcription Coregulator Binding Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Integrated Stress Response Signaling Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Beta-catenin Destruction Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of TORC2 Signaling Protein Destabilization Regulation Of Cellular Response To Heat Protein Kinase Activity Cytoplasm Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process IkappaB Kinase Activity Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of TORC2 Signaling Regulation Of Glycogen (starch) Synthase Activity Regulation Of Organelle Assembly Proteasomal Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Proteolysis Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process IkappaB Kinase Complex Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-3 Cell Cycle Phase Transition Regulation Of Type B Pancreatic Cell Development
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