CTSW

Description		cathepsin W
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endoplasmic Reticulum Endomembrane System Membrane Platelet Dense Granule Lumen Intracellular Organelle Lumen
	Molecular Function	Cysteine-type Endopeptidase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Proteolysis Immune Response Proteolysis Involved In Protein Catabolic Process
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Inflammatory bowel disease ( 23128233) Monocyte count ( 32888494)
Novel Interacting Genes		2 novel interacting genes: NPC2 RICTOR
Interacting Genes		1 interacting genes: CREB3
Entrez ID		1521
HPRD ID		03840
Ensembl ID		ENSG00000172543
Uniprot IDs		P56202
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deacetylase Activity Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Release From Viral Latency Cholesterol Storage Sterol Binding Regulation Of Isoprenoid Metabolic Process Regulation Of Cell Growth Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Locomotion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Growth Positive Regulation Of Cell Motility Induction Of Positive Chemotaxis CAMP Response Element Binding Protein Binding Positive Regulation Of Positive Chemotaxis Cholesterol Transfer Activity Intracellular Sterol Transport Glycolipid Transport Intracellular Cholesterol Transport Lysosome TORC2 Complex Enzyme-substrate Adaptor Activity TORC2 Signaling Regulation Of Establishment Of Cell Polarity Negative Regulation Of CGAS/STING Signaling Pathway Serine/threonine Protein Kinase Complex Regulation Of Establishment Or Maintenance Of Cell Polarity CGAS/STING Signaling Pathway Cholesterol Efflux Negative Regulation Of Intracellular Signal Transduction Regulation Of Monocyte Chemotaxis Lipid Storage Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Lipid Transport Transcription Coregulator Binding Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Integrated Stress Response Signaling Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
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