CNPY2 and ADRA2C

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CNPY2	ADRA2C
Name		canopy FGF signaling regulator 2	adrenoceptor alpha 2C
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum	Cytoplasm Endosome Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding
	Biological Process	Negative Regulation Of Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance	Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Adrenergic Receptor Signaling Pathway
Pathways		None	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism
Drugs		None	Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Ergotamine Tizanidine Apomorphine Paroxetine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Iloperidone OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Lurasidone Agmatine Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
GWAS		Height ( 31562340 34270706 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 26785701 )	Blood urea nitrogen levels ( 31152163 ) Lung cancer in ever smokers ( 28604730 ) Nickel levels ( 26025379 ) Urinary potassium excretion ( 31409800 )
Novel Interactors		1 novel interactors: RAB27B	1 novel interactors: WFS1
Interacting Genes		4 interacting genes: ADRA2C APP MLXIP MYLIP	17 interacting genes: CCDC24 CHCHD2 CNPY2 EIF2B1 GNAO1 HGS KLHL38 KRT34 MDFI MEIS2 MGAT5B MKRN3 P4HA3 PPP1R9B UCHL1 WWOX YWHAZ
Entrez ID		10330	152
HPRD ID		12056	00085
Ensembl ID		ENSG00000257727	ENSG00000184160
Uniprot IDs		Q9Y2B0	P18825 Q4W594
PDB IDs		Not available	6KUW
GO Terms Enriched among Interactors		Positive Regulation Of Neuron Differentiation Alpha-2A Adrenergic Receptor Binding Endosome Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Epinephrine Secretion Regulation Of Neuron Differentiation Negative Regulation Of Protein Localization Alpha2-adrenergic Receptor Activity Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Axo-dendritic Transport Intermediate-density Lipoprotein Particle Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Microtubule-based Transport Transport Along Microtubule Amylin Binding Positive Regulation Of Protein Catabolic Process Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Platelet Dense Granule Membrane Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Axon Choice Point Recognition Regulation Of Blood Circulation	None