BTLA and TNFRSF14

Number of citations of the paper that reports this interaction (PMID 15568026)
110

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		BTLA	TNFRSF14
Gene Name		B and T lymphocyte associated	tumor necrosis factor receptor superfamily, member 14
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Receptor Activity	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of Alpha-beta T Cell Proliferation	Positive Regulation Of Cytokine Secretion Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway Response To Virus Viral Process T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Migration
Pathways		Costimulation by the CD28 family Adaptive Immune System	Costimulation by the CD28 family Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Rheumatoid arthritis ( 18794853 20453842) Ulcerative colitis ( 23128233 21297633)
Protein-Protein Interactions		4 interactors: PTPN11 PTPN6 TNFRSF14 VTCN1	30 interactors: A2M APP BTLA CD160 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 KIAA1377 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		151888	8764
HPRD ID		06392	04122
Ensembl ID		ENSG00000186265	ENSG00000157873
Uniprot IDs		Q7Z6A9	Q92956
PDB IDs		2AW2	1JMA 2AW2 4FHQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Abortive Mitotic Cell Cycle Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation T Cell Costimulation Regulation Of Cell Activation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Megakaryocyte Development Positive Regulation Of Immune System Process Regulation Of Cellular Localization Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Regulation Of Immune System Process Positive Regulation Of Secretion Negative Regulation Of Immune System Process Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Secretion Cytokine-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Cellular Response To Cytokine Stimulus Regulation Of Protein Transport Immune System Process Regulation Of Secretion Positive Regulation Of Cytokine Secretion Regulation Of Establishment Of Protein Localization Regulation Of Cytokine-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Transport Type I Interferon Signaling Pathway Cellular Response To Type I Interferon	Signal Transduction Apoptotic Process Programmed Cell Death Signaling Cell Communication Cell Death Death Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteolysis Regulation Of Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Immune Response Regulation Of Endopeptidase Activity Regulation Of Immune System Process Regulation Of Peptidase Activity Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription Factor Import Into Nucleus Response To Stress Negative Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cell Activation Histone H4 Deacetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Proteolysis Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Histone H3 Deacetylation Negative Regulation Of Protein Processing Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization
Tagcloud ?		analyzer attenuator automatic cd19 cd24 das28 dropped echocardiography ef filling fs got gsh indexes lasted lef leflunomide malondialdehyde mitral obviously rose sod sv taoc velocities velocity westergren xfc xinfeng	aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
Tagcloud (Difference) ?		analyzer attenuator automatic cd19 cd24 das28 dropped echocardiography ef filling fs got gsh indexes lasted lef leflunomide malondialdehyde mitral obviously rose sod sv taoc velocities velocity westergren xfc xinfeng	aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
Tagcloud (Intersection) ?