BTLA and TNFRSF14

Number of citations of the paper that reports this interaction (PubMedID 21982860)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		BTLA	TNFRSF14
Description		B and T lymphocyte associated	TNF receptor superfamily member 14
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration
Pathways		Co-inhibition by BTLA Co-inhibition by BTLA	TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114) Ulcerative colitis ( 26398853 28067908 23128233 21297633)
Interacting Genes		4 interacting genes: PTPN11 PTPN6 TNFRSF14 VTCN1	30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		151888	8764
HPRD ID		06392	04122
Ensembl ID		ENSG00000186265	ENSG00000157873
Uniprot IDs		Q400G7 Q7Z6A9	B9A034 Q92956
PDB IDs		2AW2 6NYP 8F60 8F6L 8F6O	1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Immune System Process Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Adhesion T Cell Costimulation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Neutrophil Activation Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response Regulation Of Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Negative Regulation Of Multicellular Organismal Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of B Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Cell Activation Negative Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Type I Interferon-mediated Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cytokine Production Regulation Of Cell Adhesion Mediated By Integrin Myeloid Cell Development Regulation Of Lymphocyte Migration Positive Regulation Of Immune System Process	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity
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