BTLA and VTCN1

Number of citations of the paper that reports this interaction (PubMedID 12796776)
0

Data Source:
HPRD (in vitro, in vivo)

		BTLA	VTCN1
Description		B and T lymphocyte associated	V-set domain containing T cell activation inhibitor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation	Response To Protozoan Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Positive Regulation Of Interleukin-2 Production Positive Regulation Of T Cell Proliferation Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation
Pathways		Co-inhibition by BTLA Co-inhibition by BTLA
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Arthritis (juvenile idiopathic) ( 19116933) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		4 interacting genes: PTPN11 PTPN6 TNFRSF14 VTCN1	1 interacting genes: BTLA
Entrez ID		151888	79679
HPRD ID		06392	06429
Ensembl ID		ENSG00000186265	ENSG00000134258
Uniprot IDs		Q400G7 Q7Z6A9	Q7Z7D3
PDB IDs		2AW2 6NYP 8F60 8F6L 8F6O	4GOS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Immune System Process Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Adhesion T Cell Costimulation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Neutrophil Activation Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response Regulation Of Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Negative Regulation Of Multicellular Organismal Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of B Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Cell Activation Negative Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Type I Interferon-mediated Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cytokine Production Regulation Of Cell Adhesion Mediated By Integrin Myeloid Cell Development Regulation Of Lymphocyte Migration Positive Regulation Of Immune System Process
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