BTLA and VTCN1

Number of citations of the paper that reports this interaction (PMID 12796776)
116

Data Source:
HPRD (in vivo, in vitro)

		BTLA	VTCN1
Gene Name		B and T lymphocyte associated	V-set domain containing T cell activation inhibitor 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity	Receptor Binding
	Biological Process	Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of Alpha-beta T Cell Proliferation	Response To Protozoan Immune System Process Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Activation Interleukin-4 Secretion Interferon-gamma Secretion Positive Regulation Of Interleukin-2 Secretion
Pathways		Costimulation by the CD28 family Adaptive Immune System
Drugs
Diseases
GWAS			Arthritis (juvenile idiopathic) ( 19116933)
Protein-Protein Interactions		4 interactors: PTPN11 PTPN6 TNFRSF14 VTCN1	1 interactors: BTLA
Entrez ID		151888	79679
HPRD ID		06392	06429
Ensembl ID		ENSG00000186265	ENSG00000134258
Uniprot IDs		Q7Z6A9	Q7Z7D3
PDB IDs		2AW2	4GOS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Abortive Mitotic Cell Cycle Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation T Cell Costimulation Regulation Of Cell Activation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Megakaryocyte Development Positive Regulation Of Immune System Process Regulation Of Cellular Localization Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Regulation Of Immune System Process Positive Regulation Of Secretion Negative Regulation Of Immune System Process Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Secretion Cytokine-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Cellular Response To Cytokine Stimulus Regulation Of Protein Transport Immune System Process Regulation Of Secretion Positive Regulation Of Cytokine Secretion Regulation Of Establishment Of Protein Localization Regulation Of Cytokine-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Transport Type I Interferon Signaling Pathway Cellular Response To Type I Interferon See more	Negative Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of B Cell Proliferation Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of B Cell Activation Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Regulation Of Cell Adhesion Negative Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of Immune System Process See more
Tagcloud ?		analyzer attenuator automatic cd19 cd24 das28 dropped echocardiography ef filling fs got gsh indexes lasted lef leflunomide malondialdehyde mitral obviously rose sod sv taoc velocities velocity westergren xfc xinfeng	accessible allred baylor blia blis cellularity college copy datasets dfs drives dss fgfr2 lar logrank mes muc1 mucin negativity pdgf profiling prognoses publically subtype subtypes suppressing tnbc tnbcs worst
Tagcloud (Difference) ?		analyzer attenuator automatic cd19 cd24 das28 dropped echocardiography ef filling fs got gsh indexes lasted lef leflunomide malondialdehyde mitral obviously rose sod sv taoc velocities velocity westergren xfc xinfeng	accessible allred baylor blia blis cellularity college copy datasets dfs drives dss fgfr2 lar logrank mes muc1 mucin negativity pdgf profiling prognoses publically subtype subtypes suppressing tnbc tnbcs worst
Tagcloud (Intersection) ?