CILP2 and ANKLE1

		CILP2	ANKLE1
Description		cartilage intermediate layer protein 2	ankyrin repeat and LEM domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Alkaline Phosphatase Activity Dinucleotide Phosphatase Activity	Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Hydrolase Activity
	Biological Process		Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Repair Protein Export From Nucleus DNA Damage Response Negative Regulation Of Mitotic Recombination Nucleic Acid Metabolic Process Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Lymphoid Progenitor Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 20686565 24097068 25961943) Fasting triglyceride levels ( 32603185) LDL cholesterol ( 20686565 20864672 19060906 18193044 24097068 25961943 18193043) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 28548082) Postprandial triglyceride levels ( 32603185) Pulse pressure ( 27841878) Red cell distribution width ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Total cholesterol levels ( 28334899 28548082) Triglyceride levels ( 28334899 28548082) Triglycerides ( 18193043 18193044 19060906 20686565 20864672 24097068 25961943) Type 2 diabetes ( 22885922 28869590) Very low density lipoprotein cholesterol levels ( 28548082)	Breast cancer ( 20852631) Breast cancer (estrogen-receptor negative) ( 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Mitochondrial DNA copy number ( 30704525) Ovarian cancer ( 20852633)
Interacting Genes
Entrez ID		148113	126549
HPRD ID		16714	08801
Ensembl ID		ENSG00000160161	ENSG00000160117
Uniprot IDs		Q8IUL8	A0A494C092 A0A499FJM0 B4DSY8 B4E124 Q8NAG6
PDB IDs
Enriched GO Terms of Interacting Partners?			Dinucleotide Phosphatase Activity Alkaline Phosphatase Activity
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