CILP2 and NXNL1

		CILP2	NXNL1
Description		cartilage intermediate layer protein 2	nucleoredoxin like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Photoreceptor Outer Segment Cell Projection
	Molecular Function	Alkaline Phosphatase Activity Dinucleotide Phosphatase Activity	Protein Binding Receptor Ligand Activity
	Biological Process		Signal Transduction Photoreceptor Cell Maintenance
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 20686565 24097068 25961943) Fasting triglyceride levels ( 32603185) LDL cholesterol ( 20686565 20864672 19060906 18193044 24097068 25961943 18193043) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 28548082) Postprandial triglyceride levels ( 32603185) Pulse pressure ( 27841878) Red cell distribution width ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Total cholesterol levels ( 28334899 28548082) Triglyceride levels ( 28334899 28548082) Triglycerides ( 18193043 18193044 19060906 20686565 20864672 24097068 25961943) Type 2 diabetes ( 22885922 28869590) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes			4 interacting genes: POT1 TERF1 TERF2 TERF2IP
Entrez ID		148113	115861
HPRD ID		16714	12300
Ensembl ID		ENSG00000160161	ENSG00000171773
Uniprot IDs		Q8IUL8	Q96CM4
PDB IDs
Enriched GO Terms of Interacting Partners?			Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Positive Regulation Of Telomere Maintenance Telomeric Loop Disassembly Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA Metabolic Process Chromosome Organization Regulation Of DNA Biosynthetic Process Telomerase Activity Protection From Non-homologous End Joining At Telomere Double-stranded Telomeric DNA Binding Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Protein Localization To Chromosome, Telomeric Region Telomere Maintenance In Response To DNA Damage Chromosome Negative Regulation Of Cellular Component Organization DNA Metabolic Process Regulation Of DNA Repair Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Nuclear Body Regulation Of Organelle Organization Negative Regulation Of Establishment Of Protein Localization To Telomere
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