PDZD2

Description		PDZ domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Centriolar Satellite
	Molecular Function
	Biological Process	Cell Adhesion
Pathways
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Chronic obstructive pulmonary disease ( 29394082) Corpus callosum central volume ( 31530798) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Myocardial infarction ( 26708285) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Renal cell carcinoma ( 23184150) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Reticulocyte fraction of red cells ( 32888494) Self-reported childhood asthma in adult smokers ( 30373671) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324) Working memory ( 31598132)
Interacting Genes		5 interacting genes: ADGRB1 CST3 CTNND2 NRXN1 PKP4
Entrez ID		23037
HPRD ID		10142
Ensembl ID		ENSG00000133401
Uniprot IDs		O15018
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Postsynaptic Density Cell Adhesion Neuron Projection Morphogenesis Positive Regulation Of Synapse Assembly Anchoring Junction Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Cell-cell Adhesion Cell Junction Organization Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Cell Junction Assembly Negative Regulation Of Protein Catabolic Process Negative Regulation Of Blood Vessel Remodeling Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Regulation Of Synapse Assembly Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Transmembrane Signaling Receptor Activity Engulfment Of Apoptotic Cell Cell-cell Junction Cell Junction Plasma Membrane Vesicle Regulation Of Collagen Catabolic Process Adherens Junction Negative Regulation Of Filopodium Assembly Cerebellar Granule Cell Differentiation Postsynaptic Density Protein 95 Clustering Neuronal Signal Transduction NMDA Selective Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Trans-synaptic Protein Complex Gephyrin Clustering Involved In Postsynaptic Density Assembly AMPA Selective Glutamate Receptor Signaling Pathway Neuroligin Family Protein Binding Type 1 Fibroblast Growth Factor Receptor Binding Postsynaptic Membrane Assembly Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Junction Assembly Cell Projection Organization Synapse Organization Cell Junction Assembly Vocal Learning
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