CSF2RA and CSF2

Number of citations of the paper that reports this interaction (PubMedID 1702217)
26

Data Source:
HPRD (in vitro, in vivo)

		CSF2RA	CSF2
Description		colony stimulating factor 2 receptor subunit alpha	colony stimulating factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Growth Hormone Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Signaling Receptor Activity	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Epithelial Fluid Transport Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of DNA-templated Transcription Regulation Of Developmental Process Positive Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling
Drugs		Sargramostim KB002 Regramostim Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Clove oil	KB002
Diseases
GWAS		Mitochondrial heteroplasmy measurement ( 33731350) Schizophrenia ( 17522711)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Rheumatoid arthritis ( 22446963 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		9 interacting genes: CHUK CSF2 CSF2RB FATE1 IKBKB KIT LYN PIK3R1 RPSA	9 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 S100A6 S100P SDC2
Entrez ID		1438	1437
HPRD ID		02381	00734
Ensembl ID		ENSG00000198223	ENSG00000164400
Uniprot IDs		P15509	P04141
PDB IDs		4NKQ 4RS1	1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune System Process Immune Response Response To External Biotic Stimulus Myeloid Leukocyte Differentiation IkappaB Kinase Activity Regulation Of Cytokine Production Positive Regulation Of Leukocyte Proliferation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Positive Regulation Of Mast Cell Proliferation Fc Receptor Signaling Pathway Interleukin-5-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Scaffold Protein Binding IkappaB Kinase Complex Myeloid Cell Differentiation Histamine Secretion Phosphatidylinositol 3-kinase Activator Activity Regulation Of Mast Cell Proliferation Innate Immune Response Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Proliferation Histamine Transport CD40 Receptor Complex Transferrin Receptor Binding Mononuclear Cell Differentiation Defense Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of DNA-binding Transcription Factor Activity Leukocyte Differentiation Immune Effector Process Immune Response-regulating Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Innate Immune Response Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Immune Response Fc-epsilon Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Protein Kinase Activity Positive Regulation Of Cytokine Production Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity	Interleukin-3 Receptor Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Macrophage Cytokine Production Cytokine Receptor Activity External Side Of Plasma Membrane Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Extracellular Matrix Signaling Receptor Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cytokine Binding Positive Regulation Of Bone Mineralization Translation Termination Factor Activity Cytoplasmic Translational Termination Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Apoptotic Process Positive Regulation Of Biomineral Tissue Development Immune System Process Positive Regulation Of Ossification Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Cell Population Proliferation
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