CSF2 and SEMA7A

Data Source: HiPPIP (Novel)

		CSF2	SEMA7A
Name		colony stimulating factor 2	semaphorin 7A (JohnMiltonHagen blood group)
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Side Of Membrane Presynapse GABA-ergic Synapse
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Integrin Binding Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Epithelial Fluid Transport Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of DNA-templated Transcription Regulation Of Developmental Process Positive Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Osteoblast Differentiation Neural Crest Cell Migration Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Nervous System Development Axon Guidance Olfactory Lobe Development Cell Differentiation Positive Regulation Of Cell Migration Neuron Projection Development Positive Regulation Of Axon Extension Axon Extension Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Regulation Of Synapse Maturation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	Other semaphorin interactions Other semaphorin interactions
Drugs		KB002	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 23128233 28067908 ) Rheumatoid arthritis ( 22446963 24390342 30423114 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 )	Airflow obstruction ( 22837378 ) Alcohol consumption (drinks per week) ( 30643258 ) Apolipoprotein A1 levels ( 32203549 ) Craniofacial microsomia ( 26853712 ) HDL cholesterol levels ( 32203549 ) Hypertension ( 31879980 )
Novel Interactors		8 novel interactors: DPP7 ETF1 FBN2 IKBKE P2RX7 SEMA7A TAGLN TREML2	3 novel interactors: BBS4 CHRNA5 CSF2
Interacting Genes		9 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 S100A6 S100P SDC2	1 interacting genes: PLXNC1
Entrez ID		1437	8482
HPRD ID		00734	07081
Ensembl ID		ENSG00000164400	ENSG00000138623
Uniprot IDs		P04141	B3KMH6 F5GYX3 O75326
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS	3NVQ
GO Terms Enriched among Interactors		Interleukin-3 Receptor Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Macrophage Cytokine Production Cytokine Receptor Activity External Side Of Plasma Membrane Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Extracellular Matrix Signaling Receptor Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cytokine Binding Positive Regulation Of Bone Mineralization Translation Termination Factor Activity Cytoplasmic Translational Termination Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Apoptotic Process Positive Regulation Of Biomineral Tissue Development Immune System Process Positive Regulation Of Ossification Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Cell Population Proliferation	Regulation Of Cell Motility Microtubule Anchoring At Centrosome Positive Regulation Of Cellular Component Organization Cytokine-mediated Signaling Pathway Protein Localization To Non-motile Cilium BBSome Regulation Of Locomotion Photoreceptor Cell Outer Segment Organization Retinal Rod Cell Development Negative Regulation Of Appetite Positive Regulation Of Organelle Assembly Protein Localization To Photoreceptor Outer Segment Positive Regulation Of Multicellular Organismal Process Striatum Development Fat Pad Development Positive Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Erythrocyte Homeostasis Leptin-mediated Signaling Pathway Sensory Processing Dynactin Binding Regulation Of Non-motile Cilium Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Adult Behavior Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Organelle Assembly Cholinergic Synapse Acetylcholine-gated Monoatomic Cation-selective Channel Activity Behavioral Response To Nicotine Acetylcholine Receptor Activity Dopaminergic Synapse Acetylcholine-gated Channel Complex Neurotransmitter Receptor Complex Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of Interleukin-23 Production Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Epithelial Fluid Transport Regulation Of Interleukin-23 Production Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Neutrophil Differentiation Response To Silicon Dioxide Histamine Transport Histamine Secretion Semaphorin Receptor Complex Regulation Of Synapse Pruning