CSF2 and ETF1

		CSF2	ETF1
Description		colony stimulating factor 2	eukaryotic translation termination factor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Nucleus Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	RNA Binding Translation Release Factor Activity Peptidyl-tRNA Hydrolase Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Sequence-specific MRNA Binding
	Biological Process	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Epithelial Fluid Transport Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of DNA-templated Transcription Regulation Of Developmental Process Positive Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		KB002
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Rheumatoid arthritis ( 22446963 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061 28991256 29483656 30285260)
Interacting Genes		9 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 S100A6 S100P SDC2	8 interacting genes: CEBPA GSPT1 GSPT2 KEAP1 LIG4 OGT PPP2CA UBC
Entrez ID		1437	2107
HPRD ID		00734	02616
Ensembl ID		ENSG00000164400	ENSG00000120705
Uniprot IDs		P04141	B7Z7P8 P62495
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS	1DT9 2HST 2KTU 2KTV 2LGT 2LLX 2MQ6 2MQ9 3E1Y 3J5Y 3JAG 3JAH 3JAI 4D5N 4D61 5A8L 5LZT 5LZU 5LZV 6D90 6IP8 6XA1 6ZME 8SCB
Enriched GO Terms of Interacting Partners?		Interleukin-3 Receptor Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Macrophage Cytokine Production Cytokine Receptor Activity External Side Of Plasma Membrane Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Extracellular Matrix Signaling Receptor Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cytokine Binding Positive Regulation Of Bone Mineralization Translation Termination Factor Activity Cytoplasmic Translational Termination Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Apoptotic Process Positive Regulation Of Biomineral Tissue Development Immune System Process Positive Regulation Of Ossification Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Cell Population Proliferation	Translation Release Factor Complex Translation Release Factor Activity Stem Cell Proliferation Translational Termination Cellular Response To Lithium Ion Macromolecule Catabolic Process Response To Lithium Ion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Embryonic Placenta Development Macromolecule Metabolic Process In Utero Embryonic Development Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Granulocyte Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Macrophage Differentiation Negative Regulation Of Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Biosynthetic Process Response To Fluid Shear Stress Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Modification Process Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Establishment Of Integrated Proviral Latency Regulation Of Glycolytic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Granzyme-mediated Apoptotic Signaling Pathway Chordate Embryonic Development Multicellular Organism Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Establishment Of Viral Latency Regulation Of ATP Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cell Population Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mononuclear Cell Differentiation Response To Metal Ion Regulation Of Purine Nucleotide Metabolic Process
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