SEMA7A and PLXNC1

Number of citations of the paper that reports this interaction (PubMedID 10520995)
0

Data Source:
HPRD (in vitro, in vivo)

		SEMA7A	PLXNC1
Description		semaphorin 7A (JohnMiltonHagen blood group)	plexin C1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Side Of Membrane Presynapse GABA-ergic Synapse	Semaphorin Receptor Complex Plasma Membrane Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Integrin Binding Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Signaling Receptor Binding Protein Binding Semaphorin Receptor Activity
	Biological Process	Osteoblast Differentiation Neural Crest Cell Migration Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Nervous System Development Axon Guidance Olfactory Lobe Development Cell Differentiation Positive Regulation Of Cell Migration Neuron Projection Development Positive Regulation Of Axon Extension Axon Extension Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Regulation Of Synapse Maturation	Cell Adhesion Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Regulation Of Synapse Pruning
Pathways		Other semaphorin interactions Other semaphorin interactions	Other semaphorin interactions
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)	Alopecia areata ( 25608926) Asthma ( 31959851 32296059 34103634) Blood protein levels ( 30072576) Diastolic blood pressure ( 30578418) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602) Multiple sclerosis ( 31604244) Pulse pressure ( 30578418) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)
Interacting Genes		1 interacting genes: PLXNC1	1 interacting genes: SEMA7A
Entrez ID		8482	10154
HPRD ID		07081	05036
Ensembl ID		ENSG00000138623	ENSG00000136040
Uniprot IDs		B3KMH6 F5GYX3 O75326	O60486
PDB IDs		3NVQ	3KUZ 3NVN 3NVQ 6VXK
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Microtubule Anchoring At Centrosome Positive Regulation Of Cellular Component Organization Cytokine-mediated Signaling Pathway Protein Localization To Non-motile Cilium BBSome Regulation Of Locomotion Photoreceptor Cell Outer Segment Organization Retinal Rod Cell Development Negative Regulation Of Appetite Positive Regulation Of Organelle Assembly Protein Localization To Photoreceptor Outer Segment Positive Regulation Of Multicellular Organismal Process Striatum Development Fat Pad Development Positive Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Erythrocyte Homeostasis Leptin-mediated Signaling Pathway Sensory Processing Dynactin Binding Regulation Of Non-motile Cilium Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Adult Behavior Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Organelle Assembly Cholinergic Synapse Acetylcholine-gated Monoatomic Cation-selective Channel Activity Behavioral Response To Nicotine Acetylcholine Receptor Activity Dopaminergic Synapse Acetylcholine-gated Channel Complex Neurotransmitter Receptor Complex Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of Interleukin-23 Production Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Epithelial Fluid Transport Regulation Of Interleukin-23 Production Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Neutrophil Differentiation Response To Silicon Dioxide Histamine Transport Histamine Secretion Semaphorin Receptor Complex Regulation Of Synapse Pruning	Olfactory Lobe Development
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