ADPRH and SPSB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADPRH	SPSB1
Description		ADP-ribosylarginine hydrolase	splA/ryanodine receptor domain and SOCS box containing 1
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GO Annotations	Cellular Component	Extracellular Space	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Magnesium Ion Binding ADP-ribosylarginine Hydrolase Activity Protein Binding Hydrolase Activity Potassium Ion Binding Metal Ion Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Modification Process Protein De-ADP-ribosylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Vitiligo ( 27723757)	A body shape index ( 34021172) Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 31562340 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 30578418 27841878) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: ACD SPSB1 SRPK1 SRPK2 TFCP2	14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A
Entrez ID		141	80176
HPRD ID		04359	18106
Ensembl ID		ENSG00000144843	ENSG00000171621
Uniprot IDs		A8K6X2 B4E341 P54922	Q96BD6
PDB IDs		3HFW 6G28 6G2A 6IUX	2JK9 3F2O
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Regulation Of Viral Life Cycle MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Chromosome Regulation Of Viral Process Nucleic Acid Metabolic Process Regulation Of RNA Splicing Nuclear Speck Organization Telomere Assembly Protein-RNA Complex Assembly Magnesium Ion Binding Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Regulation Of Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Shelterin Complex Establishment Of Protein Localization To Telomere Nucleobase-containing Compound Metabolic Process Chromatin R-loop Processing Nuclear Telomere Cap Complex Protein Localization To Chromosome, Telomeric Region Regulation Of MRNA Metabolic Process Telomere Capping Protein Serine Kinase Activity Protein Phosphorylation Telomere Maintenance In Response To DNA Damage RNA Splicing Phosphorylation RNA Metabolic Process Urogenital System Development Protein Serine/threonine Kinase Activity Nuclear Body Organization Nuclear Speck Sperm DNA Condensation MRNA Processing Transcription Factor Binding Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Telomerase Holoenzyme Complex DNA Polymerase Binding Protein Modification Process	Negative Regulation Of Metabolic Process Chromatin Remodeling Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Chromatin Organization Regulation Of DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Gene Expression Transferase Activity Regulation Of DNA Recombination Histone H3 Methyltransferase Activity Negative Regulation Of Catabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Enzyme Binding Negative Regulation Of Macromolecule Metabolic Process Methyltransferase Activity Negative Regulation Of B Cell Activation Determination Of Adult Lifespan Regulation Of Cell Communication Regulation Of Signaling Regulation Of Megakaryocyte Differentiation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Meiosis I Regulation Of Intracellular Signal Transduction Negative Regulation Of Double-strand Break Repair Methylation Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisomal Matrix Male Meiotic Nuclear Division Negative Regulation Of DNA Recombination Regulation Of Cellular Response To Stress Response To Starvation GATOR1 Complex Binding Hepatocyte Growth Factor Receptor Activity
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