NEK7 and NEK9

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NEK7	NEK9
Description		NIMA related kinase 7	NIMA related kinase 9
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Microtubule	Nucleus Cytoplasm Centrosome Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Regulation Of Mitotic Cell Cycle Protein Secretion Positive Regulation Of Telomere Maintenance Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Regulation Of Chromosome Organization Interleukin-18-mediated Signaling Pathway Cellular Response To Potassium Ion NLRP3 Inflammasome Complex Assembly Positive Regulation Of Inflammatory Response Spindle Assembly Protein Maturation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Height ( 28552196) High altitude adaptation ( 28373541)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		3 interacting genes: EML4 NEK9 TERF1	16 interacting genes: BICD2 CSN2 GABARAP MAP1LC3A MAP1LC3B MBP NEK6 NEK7 NEK8 PELI2 RAN SSRP1 SUPT16H TTN UBC WEE2-AS1
Entrez ID		140609	91754
HPRD ID		06027	11386
Ensembl ID		ENSG00000151414	ENSG00000119638
Uniprot IDs		B2R8K8 Q8TDX7	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		2WQM 2WQN 5DE2 6NPY 6S73 6S75 6S76 8EJ4 8SXN	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Positive Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Cell Cycle Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Chromosome Localization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Cell Division Positive Regulation Of Shelterin Complex Assembly Regulation Of Oligodendrocyte Progenitor Proliferation Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Mitochondrial Crista Interleukin-5-mediated Signaling Pathway Regulation Of Mast Cell Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Signaling Receptor Activator Activity Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Positive Regulation Of Protein-containing Complex Assembly Shelterin Complex Meiotic Telomere Clustering Ankyrin Repeat Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Troponin Complex Transition Between Fast And Slow Fiber Mitotic Cell Cycle Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Histamine Transport Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Phosphorylation-dependent Protein Binding	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly FACT Complex Organelle Assembly Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagosome Membrane Mitophagy Structural Constituent Of Myelin Sheath Microtubule Protein Serine Kinase Activity Autophagy Of Mitochondrion Autophagosome Protein Serine/threonine Kinase Activity Cellular Component Assembly Autophagosome Assembly Nucleosome Disassembly Microtubule Cytoskeleton Organization Protein-DNA Complex Disassembly Autophagosome Organization Endomembrane System Protein-containing Complex Organization Protein Kinase Activity Phospholipid Binding Cytoskeleton Microtubule-based Process Nucleosome Binding Positive Regulation Of Metalloendopeptidase Activity Protein Localization To Myelin Sheath Abaxonal Region DRM Complex Macroautophagy Spindle Organization Kinase Activity Pyroptotic Inflammatory Response Organelle Membrane Vacuole Organization
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