CHODL and DOLK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHODL	DOLK
Description		chondrolectin	dolichol kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity
	Biological Process	Nervous System Development Muscle Organ Development Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways			Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bulimia nervosa ( 23568457) Femur bone mineral density x serum urate levels interaction ( 34046847) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatic heart disease ( 34106200)
Interacting Genes		10 interacting genes: BCL2L2 BNIP2 C2CD2L CXCL9 DOLK EBP IGFBP5 NINJ2 SCGB1D1 ZDHHC21	21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR
Entrez ID		140578	22845
HPRD ID		06261	15525
Ensembl ID		ENSG00000154645	ENSG00000175283
Uniprot IDs		A0A0C4DFS2 Q9H9P2	A0A0S2Z597 Q9UPQ8
PDB IDs
Enriched GO Terms of Interacting Partners?			Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway
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