MBTPS2

Description		membrane bound transcription factor peptidase, site 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Membrane
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Transcription Regulator Activator Activity
	Biological Process	Proteolysis NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Steroid Metabolic Process Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Maturation Bone Maturation Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones ATF6B (ATF6-beta) activates chaperones CREB3 factors activate genes CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases		Keratosis follicularis spinulosa decalvans Ichthyosis follicularis, alopecia, and photophobia syndrome
GWAS
Novel Interacting Genes		1 novel interacting genes: BDNF
Interacting Genes		1 interacting genes: ATF6B
Entrez ID		51360
HPRD ID		02243
Ensembl ID		ENSG00000012174
Uniprot IDs		O43462
PDB IDs
Enriched GO Terms of Interacting Partners?		Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of ATF6-mediated Unfolded Protein Response Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Positive Regulation Of Collateral Sprouting Nerve Growth Factor Signaling Pathway Negative Regulation Of Myotube Differentiation Collateral Sprouting Regulation Of Collateral Sprouting Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Neurotrophin Signaling Pathway
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