PIP5KL1 and PIP5K1A

Number of citations of the paper that reports this interaction (PubMedID 14701839)
0

Data Source:
HPRD (in vivo)

		PIP5KL1	PIP5K1A
Description		phosphatidylinositol-4-phosphate 5-kinase like 1	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cell Projection	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Membrane Nuclear Speck Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	Nucleotide Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol Kinase Activity	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Kinase Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity
	Biological Process	Lipid Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly
Pathways			Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Body mass index ( 26426971)
Interacting Genes		2 interacting genes: PIP5K1A PIP5K1B	16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC
Entrez ID		138429	8394
HPRD ID		15139	04470
Ensembl ID		ENSG00000167103	ENSG00000143398
Uniprot IDs		Q5T9C9	A6PW57 Q99755
PDB IDs
Enriched GO Terms of Interacting Partners?		1-phosphatidylinositol-3-phosphate 5-kinase Activity 1-phosphatidylinositol-5-kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glycerolipid Metabolic Process Phospholipid Metabolic Process Organophosphate Biosynthetic Process Lipid Biosynthetic Process Kinase Activity Ruffle Assembly Uropod MRNA Cleavage And Polyadenylation Specificity Factor Complex Fibroblast Migration Activation Of GTPase Activity Organophosphate Metabolic Process Ruffle Organization Focal Adhesion Assembly Lipid Metabolic Process Cell-substrate Junction Assembly Cell-substrate Junction Organization Phosphate-containing Compound Metabolic Process ATP Binding Keratinocyte Differentiation Nucleotide Binding Positive Regulation Of GTPase Activity Transferase Activity Ruffle Membrane Phagocytosis Epidermal Cell Differentiation Kinase Binding Ruffle Positive Regulation Of Hydrolase Activity Regulation Of Intracellular Signal Transduction Ameboidal-type Cell Migration Regulation Of GTPase Activity	Regulation Of Vesicle-mediated Transport Regulation Of Transport Regulation Of Biological Quality Vesicle-mediated Transport Intracellular Signal Transduction GTPase Activity Phospholipase D Activity GTP Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Establishment Of Localization In Cell Endocytosis Presynapse Plasma Membrane Nucleotide Binding Intracellular Signaling Cassette Response To External Biotic Stimulus Intracellular Copper Ion Homeostasis Golgi Apparatus Regulation Of Synaptic Vesicle Cycle Small GTPase-mediated Signal Transduction Negative Regulation Of B Cell Proliferation Copper Ion Homeostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Endocytosis Response To Light Stimulus Regulation Of Receptor-mediated Endocytosis Import Into Cell Response To Molecule Of Bacterial Origin Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Cell Communication Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Signaling Rac Protein Signal Transduction Phosphatidic Acid Biosynthetic Process Perinuclear Region Of Cytoplasm Regulation Of Interleukin-6 Production Negative Regulation Of Cell Population Proliferation Phosphatidic Acid Metabolic Process Regulation Of Rac Protein Signal Transduction Negative Regulation Of B Cell Activation Positive Regulation Of Inflammatory Response Glycerophospholipid Biosynthetic Process Regulation Of Tumor Necrosis Factor Production Focal Adhesion Regulation Of Signal Transduction MiRNA-mediated Gene Silencing By MRNA Destabilization Response To Radiation
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