JMY and CCDC136

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		JMY	CCDC136
Description		junction mediating and regulatory protein, p53 cofactor	coiled-coil domain containing 136
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Nucleoplasm Cytoplasm Cytoskeleton Endomembrane System Membrane Cell Leading Edge Cytoplasmic Vesicle	Acrosomal Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Transcription Coactivator Activity Actin Binding Protein Binding Microtubule Binding Arp2/3 Complex Binding	Protein Binding
	Biological Process	DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Cellular Response To Starvation Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription 'de Novo' Actin Filament Nucleation Actin Polymerization-dependent Cell Motility Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Acrosome Assembly Spermatogenesis Single Fertilization Cell Differentiation
Pathways		Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Blood and toenail selenium levels ( 25343990) Cryptococcosis in HIV infection ( 33269293) Platelet distribution width ( 32888494) Toenail selenium levels ( 25343990)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		8 interacting genes: CCDC136 EP300 GOLGA6L9 MDM2 MTUS2 RBM48 RINT1 TTC5	138 interacting genes: ABT1 AQP1 ATP5PO ATXN1 BARD1 BLOC1S6 BYSL C1orf216 C21orf58 CARD9 CBX8 CCDC120 CCDC13 CCDC146 CCDC185 CCDC187 CCDC6 CCHCR1 CDC5L CDK2AP1 CEP57 CEP57L1 CEP95 COIL CWF19L2 DDX6 DISC1 DTNB DYNC1I2 ENKD1 FAM107A FAM161A FAM161B FAM50B FLYWCH1 GFI1B HAUS1 HDAC4 HGS HMG20A HMG20B HOXB5 ISCU JAKMIP2 JMY JRK KANSL1 KAT5 KIF5B KIFC3 LCA5L LENG1 MAGEB4 MBD1 MBD3L2 MCRS1 MOS NDC80 NDN NEBL NEK6 NME7 NOP53 ODAD3 PDLIM5 PIBF1 PKN1 PKN2 POGZ PPP1R18 PRPF18 PRPF3 PRPF31 PRR35 PSMA1 PSMC5 PSMD9 RAB33A RAB33B RALBP1 RASAL3 RASSF8 SCNM1 SDHAF1 SHFL SMARCA2 SMARCE1 SYT6 TBRG1 TCEA2 TCEANC THAP7 TNNT1 TRAF3IP3 TSGA10 TSGA10IP TSPYL1 TXLNA UBQLN4 UBTFL1 USP2 WT1 ZBTB24 ZBTB38 ZBTB47 ZC2HC1C ZFP1 ZFYVE26 ZNF124 ZNF20 ZNF223 ZNF230 ZNF250 ZNF264 ZNF329 ZNF35 ZNF408 ZNF417 ZNF440 ZNF490 ZNF497 ZNF564 ZNF572 ZNF580 ZNF581 ZNF587 ZNF599 ZNF648 ZNF669 ZNF670 ZNF688 ZNF696 ZNF774 ZNF777 ZNF785 ZNF835 ZNF837 ZSCAN26
Entrez ID		133746	64753
HPRD ID		05045	10887
Ensembl ID		ENSG00000152409	ENSG00000128596
Uniprot IDs		Q8N9B5	C9JU31 Q96JN2
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Estrogen Positive Regulation Of Establishment Of Protein Localization Peptidyl-lysine Propionylation DNA Damage Response Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Protein Destabilization Histone Butyryltransferase Activity Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Nutrient Levels Histone Crotonyltransferase Activity Regulation Of Intracellular Transport Positive Regulation Of Protein Transport Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Response To Formaldehyde Cellular Response To Vitamin B1 P53 Binding Histone H2B Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Light Stimulus Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Cellular Response To UV Histone H3K18 Acetyltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Thigmotaxis Histone H3K27 Acetyltransferase Activity Regulation Of Protein Transport Positive Regulation Of Intracellular Protein Transport Peptide Crotonyltransferase Activity Positive Regulation Of Protein Localization Signal Transduction By P53 Class Mediator Peptide Lactyltransferase (CoA-dependent) Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Dsl1/NZR Complex Modulation Of Process Of Another Organism Response To Nutrient Levels	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Centrosome Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding Regulation Of Metabolic Process Cytoskeleton Chromatin Organization Microtubule-based Process Cilium Organization Nuclear Speck Microtubule Binding Spindle Pole Organelle Assembly Nuclear Proteasome Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding Nucleoplasm Regulation Of Sister Chromatid Segregation Cellular Component Assembly Microtubule Cytoskeleton Organization DNA-binding Transcription Factor Activity Centriole Protein Localization To Nucleoplasm Establishment Of Spindle Orientation Microtubule Double-stranded Methylated DNA Binding Cytosolic Proteasome Complex Centriolar Satellite Regulation Of Chromosome Segregation Regulation Of Protein Sumoylation Non-motile Cilium Assembly Histone Acetyltransferase Complex Ciliary Basal Body Establishment Of Spindle Localization
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