TMEM42 and AQP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM42	AQP3
Description		transmembrane protein 42	aquaporin 3 (Gill blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Channel Activity Identical Protein Binding
	Biological Process		Positive Regulation Of Immune System Process Response To Ischemia Renal Water Homeostasis Water Transport Glycerol Transmembrane Transport Urea Transport Response To Retinoic Acid Response To Vitamin D Odontogenesis Regulation Of Keratinocyte Differentiation Response To Calcium Ion Establishment Of Localization In Cell Transmembrane Transport Renal Water Absorption Cellular Response To Hypoxia Urea Transmembrane Transport
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs			Bisacodyl Sennosides
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756)	Lung adenocarcinoma ( 28604730 31326317) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		56 interacting genes: AQP3 AQP6 BDKRB1 CD79A CPLX4 DTX2 EBP EDA ELOVL4 ERGIC3 FAM174A FAM209A GET1 GJA8 GOLM2 GPR152 GPX8 HSD17B11 HSD17B13 LEPROTL1 LHFPL5 LMNA MFF MGAT5B MMD MMGT1 MRM1 MTIF3 NEMP1 PROP1 PSCA RABAC1 RBPMS REEP1 REEP2 REEP4 RETREG3 RHBDD1 SAR1A SCN3B SEC11C SERINC2 SHISAL1 SLC18A1 SLC34A2 SMIM14 SVOPL TLX3 TM4SF19 TMEM147 TMEM14B TMEM237 TMEM35A TMEM74 VENTX ZDHHC15	28 interacting genes: C14orf180 CD79A ERG28 ERGIC3 EVI2B FAM209A GIMAP5 GPR152 GPX8 HIBADH LEUTX LMNA MFF MGST3 MRM1 MUC1 OLFM4 PLD2 PLP2 SAR1A SGPL1 SSMEM1 STX1A TMEM107 TMEM42 TMEM86A TNF VASN
Entrez ID		131616	360
HPRD ID		15540	08970
Ensembl ID		ENSG00000169964	ENSG00000165272
Uniprot IDs		Q69YG0	A0A2R8Y2R4 B4E034 Q92482
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Steroid Dehydrogenase Activity Endoplasmic Reticulum Organization Establishment Of Protein Localization To Membrane Protein Insertion Into Membrane Protein Insertion Into ER Membrane Acetylcholine Receptor Regulator Activity Renal Water Transport Localization Within Membrane	Membrane
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