SPMIP4 and CLCNKA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPMIP4	CLCNKA
Description		sperm microtubule inner protein 4	chloride voltage-gated channel Ka
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cilium Motile Cilium Cell Projection	Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex
	Molecular Function	Protein Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding
	Biological Process		Monoatomic Ion Transport Chloride Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Renal Absorption Chloride Transmembrane Transport
Pathways			Stimuli-sensing channels
Drugs			Niflumic acid Talniflumate
Diseases			Bartter syndrome
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: APP BCL6 CLCNKA CLIC3 CYSRT1 HSF2BP KCTD9 KLHL40 OIP5 PFDN5 TEKT5	22 interacting genes: CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SPMIP4 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511
Entrez ID		136895	1187
HPRD ID		12919	03608
Ensembl ID		ENSG00000153790	ENSG00000186510
Uniprot IDs		Q8N865	P51800
PDB IDs			2PFI
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Myeloid Cell Development Regulation Of Protein Import Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of Amyloid Fibril Formation Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chloride Channel Complex Chloride Transmembrane Transport Chloride Channel Activity RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Protein-disulfide Reductase (glutathione) Activity Pericentric Heterochromatin Organization CENP-A Recruiting Complex	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epidermis Development Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Establishment Of Skin Barrier DNA-binding Transcription Factor Activity Type II Interferon Binding Coated Vesicle Membrane Skin Epidermis Development Cellular Developmental Process Tissue Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skin Development E-box Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein K33-linked Ubiquitination
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