ADH6 and SLC39A8

		ADH6	SLC39A8
Description		alcohol dehydrogenase 6 (class V)	solute carrier family 39 member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Lysosome Lysosomal Membrane Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Organelle Membrane
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding	Zinc Ion Transmembrane Transporter Activity Symporter Activity Metal Ion Transmembrane Transporter Activity Monoatomic Cation:bicarbonate Symporter Activity Zinc:bicarbonate Symporter Activity
	Biological Process	Retinol Metabolic Process Retinoic Acid Metabolic Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Protein N-linked Glycosylation Arginine Metabolic Process Monoatomic Ion Transport Cobalt Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Mercury Ion Transport Bicarbonate Transport Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Manganese Ion Homeostasis Extracellular Matrix Organization Regulation Of Membrane Potential Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Inflammatory Response Transmembrane Transport Leukocyte Adhesion To Arterial Endothelial Cell Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Iron Ion Import Across Plasma Membrane Cellular Detoxification Of Cadmium Ion Cartilage Homeostasis Mitochondrial Manganese Ion Transmembrane Transport
Pathways		Ethanol oxidation	Zinc influx into cells by the SLC39 gene family
Drugs
Diseases
GWAS		Alcohol dependence ( 23456092) Alcohol use disorder (consumption score) ( 30336701 30940813) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Aspartate aminotransferase levels ( 33547301) Esophageal cancer ( 19698717) QRS duration ( 23534349) Regular attendance at a pub or social club ( 29970889) Serum alkaline phosphatase levels ( 33547301)	A body shape index ( 34021172) Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30336701 30940813 33861876) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Allergic disease (asthma, hay fever or eczema) ( 29679657) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anterior thalamic nuclei volume ( 34006833) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Blood pressure ( 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 25673413 26961502 28448500 28552196 29273807 29381148) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 26604143 33045005) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 21909115 27618452 27841878 28739976 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil percentage of white cells ( 32888494) Erythrocyte cadmium concentration in never smokers ( 27005419) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol ( 20686565 24097068 25961943 30275531) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hypertension ( 21909115 31879980) Inflammatory bowel disease ( 28067908) Initial pursuit acceleration ( 29064472) Intelligence (MTAG) ( 29326435) Lateral thalamic nuclei volume ( 34006833) LDL cholesterol levels ( 32203549) Left-handedness ( 32989287) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Manganese levels ( 26025379) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Multisite chronic pain ( 31194737 33830993) NT-proBNP levels in acute coronary syndrome ( 26908625) Obese vs. thin ( 30677029) Parkinson's disease ( 32201043) Platelet distribution width ( 27863252 32888494) Problematic alcohol use ( 32451486) Red blood cell count ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656) Serum total protein levels ( 29403010) Shoulder impingement or rotator cuff tear ( 33482370) Sleep duration (short sleep) ( 30846698) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 21909115 27618447 27618452 27841878 28739976 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731 32203549) Voxel-wise structural brain imaging measurements ( 30649180) vWF levels ( 30586737) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 TNIP1	1 interacting genes: PTGER4
Entrez ID		130	64116
HPRD ID		00067	12286
Ensembl ID		ENSG00000172955	ENSG00000138821
Uniprot IDs		P28332 Q8IUN7	Q9C0K1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Post-translational Protein Modification Regulation Of Cellular Senescence Regulation Of Canonical NF-kappaB Signal Transduction Leukocyte Cell-cell Adhesion Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Angiotensin Receptor Binding Regulation Of Intracellular Signal Transduction Response To Isolation Stress GMP Binding Forebrain Astrocyte Development Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of MDA-5 Signaling Pathway Cellular Detoxification Of Cadmium Ion Monoatomic Cation:bicarbonate Symporter Activity Cartilage Homeostasis	Bone Development Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Ovarian Cumulus Expansion Prostaglandin E Receptor Activity Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Nucleosome Array Spacer Activity Zygotic Specification Of Dorsal/ventral Axis
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