PIGU and GPAA1

Number of citations of the paper that reports this interaction (PubMedID 22939629)
52

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		PIGU	GPAA1
Description		phosphatidylinositol glycan anchor biosynthesis class U	glycosylphosphatidylinositol anchor attachment 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane GPI-anchor Transamidase Complex	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding
	Biological Process	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein Regulation Of Receptor Signaling Pathway Via JAK-STAT GPI Anchored Protein Biosynthesis	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Attachment of GPI anchor to uPAR	Attachment of GPI anchor to uPAR
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Brown vs. black hair color ( 30531825) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous melanoma or hair colour ( 32341527) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Melanoma ( 28212542) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Smoking status (ever vs never smokers) ( 30643258) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Weight ( 28552196)	Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944)
Interacting Genes		4 interacting genes: F2RL1 GPAA1 KASH5 WEE2-AS1	10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13
Entrez ID		128869	8733
HPRD ID		12250	04334
Ensembl ID		ENSG00000101464	ENSG00000197858
Uniprot IDs		Q9H490	O43292
PDB IDs		7W72 7WLD 8IMX 8IMY	7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream GPI-anchor Transamidase Activity Meiotic Spindle Pole Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Killing Of Cells Of Another Organism Thrombin-activated Receptor Activity GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Pre-mRNA 5'-splice Site Binding Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Attachment Of GPI Anchor To Protein Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Protein Retention In ER Lumen Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation MRNA 5'-splice Site Recognition GPI Anchor Binding Telomere Localization Regulation Of Toll-like Receptor 3 Signaling Pathway Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Glomerular Filtration Maintenance Of Protein Localization In Endoplasmic Reticulum Meiotic Nuclear Membrane Microtubule Tethering Complex Lateral Element Regulation Of Defense Response To Bacterium Pseudopodium Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Protein Depolymerization Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Superoxide Anion Generation Cell-cell Junction Maintenance Positive Regulation Of Superoxide Anion Generation G-protein Beta-subunit Binding Dynein Complex Binding U1 SnRNP Positive Regulation Of Positive Chemotaxis Positive Regulation Of Rho Protein Signal Transduction	GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process
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