TBC1D20 and APOC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D20	APOC2
Description		TBC1 domain family member 20	apolipoprotein C2
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding Enzyme Activator Activity Lipid Binding Phospholipase Activator Activity Identical Protein Binding Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity Molecular Function Activator Activity
	Biological Process	Acrosome Assembly Lens Development In Camera-type Eye Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Spermatogenesis Male Gonad Development Vesicle Organization Vesicle-mediated Transport Virion Assembly Lipid Droplet Organization Camera-type Eye Development Positive Regulation Of GTPase Activity Host-mediated Activation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Lens Fiber Cell Morphogenesis Seminiferous Tubule Development COPII-coated Vesicle Cargo Loading Regulation Of Cilium Assembly Positive Regulation Of ER To Golgi Vesicle-mediated Transport	Lipid Metabolic Process Lipid Transport Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Lipoprotein Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis
Pathways		COPII-mediated vesicle transport TBC/RABGAPs	Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Copper
Diseases			Hyperlipoproteinemia, type I
GWAS		Night sleep phenotypes ( 27126917)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) HDL cholesterol levels ( 28334899) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 20864672 20686565 19060906 18193044) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Low density lipoprotein cholesterol levels ( 28548082) Quantitative traits ( 19197348) Total cholesterol levels ( 28548082 28334899) Triglyceride levels ( 28334899) Triglycerides ( 20686565) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		7 interacting genes: ADRA1A APOC2 APOC4 APP AQP6 EBP TMEM14B	28 interacting genes: APOL2 BCL2L2 CFTR CRYAB DIABLO GAD2 GSDMA IFI27 LETMD1 LPL MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SNCA SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 TTPA UBQLN1 UBQLN2
Entrez ID		128637	344
HPRD ID		15472	07457
Ensembl ID		ENSG00000125875	ENSG00000234906
Uniprot IDs		Q96BZ9 Q9Y2V8	A0A024R0T9 P02655
PDB IDs		4HL4 4HLQ	1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Low-density Lipoprotein Particle Negative Regulation Of Blood Circulation Molecular Function Activator Activity Lipoprotein Metabolic Process Acylglycerol Homeostasis Triglyceride Homeostasis Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Developmental Cell Growth Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Pilomotor Reflex Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Alpha1-adrenergic Receptor Activity Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Steroid Delta-isomerase Activity Cholestenol Delta-isomerase Activity Positive Regulation Of Synaptic Transmission Negative Regulation Of Very-low-density Lipoprotein Particle Clearance	Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Membrane Very-low-density Lipoprotein Particle Clearance Mitochondrial Outer Membrane Mitochondrial Membrane Organization Inner Mitochondrial Membrane Organization Mitochondrial Crista Junction Lipoprotein Particle Binding Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Transport MICOS Complex Triglyceride-rich Lipoprotein Particle Remodeling SAM Complex MIB Complex Organelle Organization Host-mediated Perturbation Of Viral Genome Replication Cristae Formation Regulation Of Transport Chylomicron Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Mitochondrial Membrane Host-mediated Perturbation Of Viral Process Regulation Of Vesicle-mediated Transport Neutral Lipid Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Synaptic Vesicle Priming Positive Regulation Of ERAD Pathway Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Regulation Of Amyloid-beta Clearance Calcium Ion Homeostasis Mitochondrial Calcium Ion Homeostasis Protein Binding Membrane Organization Host-mediated Perturbation Of Symbiont Process Regulation Of ERAD Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Sterol Metabolic Process Monoatomic Ion Homeostasis Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier
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