LRRIQ3 and NCK2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LRRIQ3	NCK2
Gene Name		leucine-rich repeats and IQ motif containing 3	NCK adaptor protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane
	Molecular Function		SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity
	Biological Process		Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways			Signaling by PDGF Ephrin signaling Axon guidance Activation of Rac Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling Nephrin interactions Signaling by Robo receptor VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Cardiac Troponin-T levels ( 23247143)	Addiction ( 23533358)
Protein-Protein Interactions		1 interactors: NCK2	80 interactors: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B
Entrez ID		127255	8440
HPRD ID		14485	05378
Ensembl ID		ENSG00000162620	ENSG00000071051
Uniprot IDs		A6PVS8	E7ERP6 O43639
PDB IDs			1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Signal Complex Assembly Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Lamellipodium Assembly Lamellipodium Organization Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Receptor Activity Positive Regulation Of Protein Polymerization Regulation Of T Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Translation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Cell Projection Assembly Regulation Of T Cell Activation Positive Regulation Of Cell Activation Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Protein Phosphorylation Leukocyte Cell-cell Adhesion Regulation Of Cellular Component Size Homotypic Cell-cell Adhesion Regulation Of Protein Complex Assembly Cellular Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Axon Guidance	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Signaling Movement Of Cell Or Subcellular Component Cell Communication Immune Response Locomotion Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Peptidyl-tyrosine Phosphorylation Axon Guidance Intracellular Signal Transduction Cell Migration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Anatomical Structure Development Positive Regulation Of Protein Metabolic Process Cell Development Gene Expression Regulation Of Cellular Process Immune System Process Cell Motility System Development Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Multicellular Organismal Development Chemotaxis Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Axon Development Developmental Process Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development
Tagcloud ?			accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Difference) ?			accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Intersection) ?