SEC61G and PEX12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC61G	PEX12
Description		SEC61 translocon subunit gamma	peroxisomal biogenesis factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Ssh1 Translocon Complex	Peroxisome Peroxisomal Membrane Cytosol Membrane Peroxisomal Importomer Complex
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Activator Activity
	Biological Process	Protein Targeting Intracellular Protein Transport Protein Transport Post-translational Protein Targeting To Membrane, Translocation Protein Targeting To ER	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Targeting To Peroxisome Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Metabolite levels ( 23823483) Systemic lupus erythematosus ( 24871463) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: AQP6 CREB3 CREB3L1 FAM209A LCN2 LRRC25 PEX12 SEC61A1 SFTPC TMEM51	36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA
Entrez ID		23480	5193
HPRD ID		15318	03455
Ensembl ID		ENSG00000132432	ENSG00000108733
Uniprot IDs		P60059	O00623
PDB IDs		6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transmembrane Transport Protein Transmembrane Transporter Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Protein Transmembrane Transport Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Pronephric Nephron Development Regulation Of Response To Endoplasmic Reticulum Stress Siderophore Transport Cellular Response To Reactive Oxygen Species Peroxisomal Importomer Complex Extracellular Matrix Constituent Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Endoplasmic Reticulum Membrane Signal Sequence Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Response To Herbicide Regulation Of Hippocampal Neuron Apoptotic Process Response To Mycotoxin Release From Viral Latency Regulation Of Iron Ion Transport Response To Blue Light Protein Import Into Peroxisome Matrix, Substrate Release Multivesicular Body Lumen Alveolar Lamellar Body CCR1 Chemokine Receptor Binding Sec61 Translocon Complex Response To Reactive Oxygen Species Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Lamellar Body Monoatomic Anion Channel Activity Renal Water Transport SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation	Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Membrane Targeting Sequence Binding Endoplasmic Reticulum Membrane Membrane Peroxisome Organization Intracellular Protein Transmembrane Transport Fatty Acid Metabolic Process Endoplasmic Reticulum Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Targeting To Peroxisome Protein Carrier Chaperone Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Monocarboxylic Acid Metabolic Process Protein Transmembrane Transport Pexophagy Triglyceride Catabolic Process Response To Oxidative Stress Cellular Response To Oxidative Stress Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Transmembrane Transporter Activity Receptor Recycling Cellular Response To Reactive Oxygen Species Fatty Acid Biosynthetic Process Acylglycerol Catabolic Process Lipid Catabolic Process Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Membrane Organization Negative Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Ssh1 Translocon Complex 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity
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