ZNF441 and PCSK6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF441	PCSK6
Description		zinc finger protein 441	proprotein convertase subtilisin/kexin type 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Endomembrane System Membrane Extracellular Matrix
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Nerve Growth Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Plasma Lipoprotein Particle Remodeling
Pathways		Generic Transcription Pathway	Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		8 interacting genes: CYSRT1 DVL3 MDFI PCSK6 SPRY1 STX1A TEX48 YPEL3	7 interacting genes: CACNA1A DYRK1A FLG PCSK5 PMCH RCN3 ZNF441
Entrez ID		126068	5046
HPRD ID		15794	01329
Ensembl ID		ENSG00000197044	ENSG00000140479
Uniprot IDs		Q8N8Z8	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs
Enriched GO Terms of Interacting Partners?			Phosphoethanolamine Phosphatase Activity Response To Vitamin B6 Futile Creatine Cycle Phosphoamidase Activity Extracellular Membrane-bounded Organelle Response To Amyloid-beta Cellular Response To Amyloid-beta Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Negative Regulation Of Synaptic Transmission, Dopaminergic Melanin-concentrating Hormone Activity Neurofilament Cytoskeleton Fast-twitch Skeletal Muscle Fiber Contraction Protein-fructosamine 3-kinase Activity Fructosamine Metabolic Process Protein Deglycation Protein-ribulosamine 3-kinase Activity Fructoselysine Metabolic Process
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