AGAP1 and ALPI

		AGAP1	ALPI
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	alkaline phosphatase, intestinal
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Endosome	Extracellular Region Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding	Magnesium Ion Binding Protease Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Protein Transport Regulation Of Modification Of Postsynaptic Structure	Dephosphorylation
Pathways			Synthesis of PA Post-translational modification: synthesis of GPI-anchored proteins Digestion
Drugs			Terpinen-4-ol
Diseases
GWAS		Adult body size ( 32376654) Anterior thalamic nuclei volume ( 34006833) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Hepcidin/ferritin ratio ( 27846281) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: APP ARF1 ARF6 CDC42 DYRK1A GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 WEE2-AS1 ZNF534	8 interacting genes: BICD1 HSPB1 IRF5 KRTAP10-3 KRTAP10-8 KRTAP10-9 NOD2 NOTCH2NLA
Entrez ID		116987	248
HPRD ID		16359	01376
Ensembl ID		ENSG00000157985	ENSG00000163295
Uniprot IDs		B2RZG9 E7EUN2 Q9UPQ3	P09923
PDB IDs		7EB6
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization GTP Binding Membrane Invagination Thioesterase Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis G Protein Activity Regulation Of Cell-substrate Junction Organization Guanylate Cyclase Complex, Soluble Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Positive Regulation Of Locomotion Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Neuron Projection Organization Regulation Of Receptor-mediated Endocytosis Cell Junction Organization Regulation Of Actin Filament Organization Positive Regulation Of Cytokinesis Negative Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Nucleotide Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Signaling Receptor Activator Activity Positive Regulation Of Stress Fiber Assembly Guanylate Cyclase Activity Regulation Of Cytoskeleton Organization GTPase Activity Establishment Or Maintenance Of Cell Polarity Circulatory System Process Nitric Oxide-cGMP-mediated Signaling Regulation Of Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Glutamatergic Synapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Podosome Assembly Flavonoid Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly	Cellular Response To Peptidoglycan Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Response To Peptidoglycan Keratin Filament Protein Kinase Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Muramyl Dipeptide Intermediate Filament Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Beta Production Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Interleukin-1 Production Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Detection Of Peptidoglycan Regulation Of Notch Signaling Pathway Ubiquitin Binding Regulation Of Interleukin-1 Beta Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteinase Activated Receptor Binding Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Protein Kinase C Inhibitor Activity Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Involved In Immune Response Minus-end-directed Organelle Transport Along Microtubule Regulation Of Protein Kinase C Signaling Anion Binding Postsynaptic Endosome Constitutive Secretory Pathway Transport Along Microtubule Positive Regulation Of Protein Localization To Centrosome Secretory Vesicle Virion Assembly Cytoskeleton-dependent Intracellular Transport Regulation Of Tumor Necrosis Factor Production Anterograde Axonal Protein Transport Innate Immune Response-activating Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intestinal Stem Cell Homeostasis Protein Linear Polyubiquitination Carbohydrate Derivative Binding
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