TSEN15 and TSEN34

Number of citations of the paper that reports this interaction (PMID 15109492)
44

Data Source:
HPRD (two hybrid)

		TSEN15	TSEN34
Gene Name		TSEN15 tRNA splicing endonuclease subunit	TSEN34 tRNA splicing endonuclease subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Nucleolus
	Molecular Function	TRNA-intron Endonuclease Activity	TRNA-intron Endonuclease Activity Nucleic Acid Binding Lyase Activity
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	TRNA-type Intron Splice Site Recognition And Cleavage MRNA Processing RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways
Drugs
Diseases
GWAS		Height ( 20881960)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: EXOSC4 LMO4 NBPF3 TSEN34	2 interactors: HNRNPD TSEN15
Entrez ID		116461	79042
HPRD ID		12292	10038
Ensembl ID		ENSG00000198860	ENSG00000170892
Uniprot IDs		B1ALV0 Q8WW01	B4DT51 Q9BSV6
PDB IDs		2GW6
Enriched GO Terms of Interacting Partners?		RNA Phosphodiester Bond Hydrolysis TRNA-type Intron Splice Site Recognition And Cleavage Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear MRNA Surveillance RNA Surveillance DNA Deamination Histone MRNA Catabolic Process NcRNA Metabolic Process MRNA Metabolic Process Spinal Cord Association Neuron Differentiation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Maturation Of 5.8S RRNA Regulation Of Cell Fate Specification Ventral Spinal Cord Interneuron Differentiation RNA Metabolic Process Histone MRNA Metabolic Process Dorsal Spinal Cord Development Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Cell Fate Commitment Spinal Cord Motor Neuron Differentiation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ventricular Septum Development Ventral Spinal Cord Development Nucleobase-containing Compound Metabolic Process Thymus Development Cell Differentiation In Spinal Cord Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Cellular Nitrogen Compound Metabolic Process Cardiac Septum Development DNA Modification Nitrogen Compound Metabolic Process Neural Tube Closure Spinal Cord Development Cardiac Ventricle Development	RNA Splicing MRNA Processing Circadian Regulation Of Translation MRNA Metabolic Process RNA Processing TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of MRNA Stability Regulation Of RNA Stability RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Translation
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