TSEN15 and TSEN34

Number of citations of the paper that reports this interaction (PubMedID 15109492)
0

Data Source:
HPRD (two hybrid)

		TSEN15	TSEN34
Description		tRNA splicing endonuclease subunit 15	tRNA splicing endonuclease subunit 34
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding Protein Binding	TRNA-intron Lyase Activity Nucleic Acid Binding Lyase Activity
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing TRNA Processing	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus	tRNA processing in the nucleus
Drugs
Diseases			Pontocerebellar hypoplasia
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 34021172)	Obesity-related traits ( 23251661)
Interacting Genes		34 interacting genes: AIF1L ARID5A ASB12 CCDC33 DDIT4L DNAAF6 ENKD1 ERBB2 EXOSC4 GORASP2 HSF2BP IKZF3 INCA1 LMO2 LMO4 LRIF1 MEI4 MIPOL1 NBPF3 PBX4 PHOSPHO2 PLB1 POLR2G POU6F2 REL TASOR2 TEPSIN TLE5 TSEN34 TSSK2 USP54 ZMAT2 ZNF554 ZNF620	2 interacting genes: HNRNPD TSEN15
Entrez ID		116461	79042
HPRD ID		12292	10038
Ensembl ID		ENSG00000198860	ENSG00000170892
Uniprot IDs		A0A2R8YDU8 A0A2U3TZM3 B1ALV0 E9PPN1 Q8WW01	A0A590UJW4 B4DT51 E7EQB3 Q9BSV6
PDB IDs		2GW6 6Z9U 7UXA 7ZRZ 8HMY 8HMZ 8ISS	6Z9U 7UXA 7ZRZ 8HMY 8HMZ 8ISS
Enriched GO Terms of Interacting Partners?			Hepatocyte Dedifferentiation Cellular Response To Putrescine Circadian Regulation Of Translation Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Nucleic Acid Binding Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding CRD-mediated MRNA Stabilization Regulation Of Telomere Capping Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Cellular Response To Nitric Oxide Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Cellular Response To Reactive Nitrogen Species Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Processing Response To Nitric Oxide Response To Ether Positive Regulation Of Telomere Maintenance Via Telomerase Response To Salt Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding MRNA 3'-UTR AU-rich Region Binding Cellular Response To Estradiol Stimulus Regulation Of Cytoplasmic Translation Response To Electrical Stimulus Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Cerebellum Development Regulation Of Telomere Maintenance Via Telomere Lengthening RNA Metabolic Process MRNA Stabilization Positive Regulation Of Telomere Maintenance Negative Regulation Of MRNA Catabolic Process RNA Stabilization Cellular Response To Amino Acid Stimulus Regulation Of DNA Biosynthetic Process Positive Regulation Of MRNA Catabolic Process Response To Amino Acid MRNA Destabilization Response To Estradiol RNA Destabilization Negative Regulation Of RNA Catabolic Process Regulation Of Circadian Rhythm Positive Regulation Of Chromosome Organization Negative Regulation Of MRNA Metabolic Process
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