TSEN15 and NBPF3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSEN15	NBPF3
Gene Name		TSEN15 tRNA splicing endonuclease subunit	neuroblastoma breakpoint family, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus	Cytoplasm
	Molecular Function	TRNA-intron Endonuclease Activity
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways
Drugs
Diseases
GWAS		Height ( 20881960)	Folate pathway vitamin levels ( 19744961) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Phosphorus levels ( 20558539)
Protein-Protein Interactions		4 interactors: EXOSC4 LMO4 NBPF3 TSEN34	4 interactors: ANK1 APP EWSR1 TSEN15
Entrez ID		116461	84224
HPRD ID		12292	10633
Ensembl ID		ENSG00000198860	ENSG00000142794
Uniprot IDs		B1ALV0 Q8WW01	Q9H094
PDB IDs		2GW6
Enriched GO Terms of Interacting Partners?		RNA Phosphodiester Bond Hydrolysis TRNA-type Intron Splice Site Recognition And Cleavage Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear MRNA Surveillance RNA Surveillance DNA Deamination Histone MRNA Catabolic Process NcRNA Metabolic Process MRNA Metabolic Process Spinal Cord Association Neuron Differentiation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Maturation Of 5.8S RRNA Regulation Of Cell Fate Specification Ventral Spinal Cord Interneuron Differentiation RNA Metabolic Process Histone MRNA Metabolic Process Dorsal Spinal Cord Development Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Cell Fate Commitment Spinal Cord Motor Neuron Differentiation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ventricular Septum Development Ventral Spinal Cord Development Nucleobase-containing Compound Metabolic Process Thymus Development Cell Differentiation In Spinal Cord Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Cellular Nitrogen Compound Metabolic Process Cardiac Septum Development DNA Modification Nitrogen Compound Metabolic Process Neural Tube Closure Spinal Cord Development Cardiac Ventricle Development	Transition Metal Ion Homeostasis Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Axon Choice Point Recognition Exocytosis Neuron Remodeling Axon Guidance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Processing Maintenance Of Cell Polarity Cellular Nitrogen Compound Metabolic Process Metal Ion Homeostasis Secretion By Cell Axonogenesis TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Ion Homeostasis Axon Development RNA Processing Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Copper Ion Homeostasis Suckling Behavior Secretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Morphogenesis Involved In Differentiation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Porphyrin-containing Compound Biosynthetic Process RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neuron Projection Development Protein Targeting To Plasma Membrane Erythrocyte Development Cell Projection Morphogenesis
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