TSEN34

Name	tRNA splicing endonuclease subunit 34
Structure
Interactors	2 interactors: HNRNPD TSEN15
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Nucleolus
	Molecular Function	TRNA-intron Lyase Activity Nucleic Acid Binding Lyase Activity
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing TRNA Processing
Pathways	tRNA processing in the nucleus
Diseases	Pontocerebellar hypoplasia
GWAS	Obesity-related traits ( 23251661 )
Entrez ID	79042
HPRD ID	10038
Ensembl ID	ENSG00000170892
Uniprot IDs	A0A590UJW4 B4DT51 E7EQB3 Q9BSV6
PDB IDs	6Z9U 7UXA 7ZRZ 8HMY 8HMZ 8ISS
GO Terms Enriched among Interactors ?	Hepatocyte Dedifferentiation Cellular Response To Putrescine Circadian Regulation Of Translation Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Nucleic Acid Binding Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding CRD-mediated MRNA Stabilization Regulation Of Telomere Capping Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Cellular Response To Nitric Oxide Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Cellular Response To Reactive Nitrogen Species Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Processing Response To Nitric Oxide Response To Ether Positive Regulation Of Telomere Maintenance Via Telomerase Response To Salt Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding MRNA 3'-UTR AU-rich Region Binding Cellular Response To Estradiol Stimulus Regulation Of Cytoplasmic Translation Response To Electrical Stimulus Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Cerebellum Development Regulation Of Telomere Maintenance Via Telomere Lengthening RNA Metabolic Process MRNA Stabilization Positive Regulation Of Telomere Maintenance Negative Regulation Of MRNA Catabolic Process RNA Stabilization Cellular Response To Amino Acid Stimulus Regulation Of DNA Biosynthetic Process Positive Regulation Of MRNA Catabolic Process Response To Amino Acid MRNA Destabilization Response To Estradiol RNA Destabilization Negative Regulation Of RNA Catabolic Process Regulation Of Circadian Rhythm Positive Regulation Of Chromosome Organization Negative Regulation Of MRNA Metabolic Process