DNTTIP1 and E2F6

Number of citations of the paper that reports this interaction (PubMedID 23082233)
45

Data Source:
BioGRID (two hybrid)

		DNTTIP1	E2F6
Description		deoxynucleotidyltransferase terminal interacting protein 1	E2F transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Chromosome Nucleolus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex MLL1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Protein Binding Nucleosome Binding Protein Homodimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Negative Regulation of CDH1 Gene Transcription	G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Mean platelet volume ( 27863252 32888494) Temporal pole volume ( 31530798)	Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)
Interacting Genes		12 interacting genes: ANP32B DNTT E2F6 EAF1 HMBOX1 HOMEZ KDM1A MAGEA6 MFAP1 PICK1 TRIM55 TRIM63	27 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		116092	1876
HPRD ID		16831	04251
Ensembl ID		ENSG00000101457	ENSG00000169016
Uniprot IDs		Q9H147	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs		2MWI 4D6K 6Z2J 6Z2K
Enriched GO Terms of Interacting Partners?		Nucleus Telomeric DNA Binding	Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Constitutive Heterochromatin Formation Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation PcG Protein Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Heterochromatin ESC/E(Z) Complex Positive Regulation Of Transcription By RNA Polymerase II PRC1 Complex Regulation Of Cell Cycle Histone H3K27 Trimethyltransferase Activity Nucleosome Binding Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Zinc Ion Binding
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