MALSU1 and CHMP2B

Number of citations of the paper that reports this interaction (PubMedID 16730941)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MALSU1	CHMP2B
Description		mitochondrial assembly of ribosomal large subunit 1	charged multivesicular body protein 2B
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Postsynaptic Density Membrane Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Glutamatergic Synapse Amphisome Membrane
	Molecular Function	Protein Binding Ribosomal Large Subunit Binding Mitochondrial Large Ribosomal Subunit Binding	Protein Binding Protein Domain Specific Binding Cadherin Binding
	Biological Process	Negative Regulation Of Translation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Negative Regulation Of Mitochondrial Translation Negative Regulation Of Ribosome Biogenesis	Plasma Membrane Repair Autophagy Nucleus Organization Endosome Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Modulation Of Chemical Synaptic Transmission Cognition Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Neuron Cellular Homeostasis Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Modification Of Postsynaptic Structure Regulation Of Postsynapse Organization Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport ESCRT III Complex Disassembly
Pathways		Mitochondrial ribosome-associated quality control	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS			Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		13 interacting genes: CHMP2B DCTD INCA1 LMO3 MEOX2 MYBPHL NTAQ1 PLEKHG4 SP6 TRIM55 TRIM63 ZFP90 ZNF426	14 interacting genes: ATP5F1C CENPF CFTR CHMP3 DPY30 FBXO7 MALSU1 PHGDH PNMA1 SNCA TERF2IP TRAF2 USP54 USP8
Entrez ID		115416	25978
HPRD ID		12918	13174
Ensembl ID		ENSG00000156928	ENSG00000083937
Uniprot IDs		Q96EH3	A0A087WW88 B2RE76 Q9UQN3
PDB IDs		5OOL 5OOM 7A5H 7A5J 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF5 7OF7 7OI6 7OI7 7OI8 7OI9 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 8K2B 8PK0 8QSJ 8QU5	2JQK
Enriched GO Terms of Interacting Partners?			Organelle Localization Midbody Dynein Complex Binding Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission TORC2 Complex Disassembly K63-linked Deubiquitinase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Phosphoglycerate Dehydrogenase Activity Negative Regulation Of Mitochondrial Translation
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