AGPAT4 and AQP12B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGPAT4	AQP12B
Description		1-acylglycerol-3-phosphate O-acyltransferase 4	aquaporin 12B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane	Cytoplasm Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity	Protein Binding Water Channel Activity Channel Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process CDP-diacylglycerol Biosynthetic Process	Water Transport Transmembrane Transport
Pathways		Synthesis of PA
Drugs
Diseases
GWAS		Anxiety in major depressive disorder ( 24047446) Diastolic blood pressure ( 30224653) Energy expenditure (24h) ( 28476931) Fear of pain ( 28701861) Lipoprotein (a) - cholesterol levels ( 25575512) Lipoprotein (a) levels ( 26377243) Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: AQP12B AQP6 CNR2 CREB3L1 ERGIC3 FCGR2A FCRL3 FFAR2 GPR101 HSD17B11 HSD17B13 JAGN1 LEPROTL1 LEUTX LRRC25 MFF MGST3 REEP4 REL RETREG3 SCN3B SLC10A6 SLC35H1 SLC71A2 SLC7A8 SPACA1 TMEM14B TMEM31 TMX2	4 interacting genes: AGPAT4 STRIT1 TMEM97 TRARG1
Entrez ID		56895	653437
HPRD ID		12437	19650
Ensembl ID		ENSG00000026652	ENSG00000185176
Uniprot IDs		Q9NRZ5	A6NM10 Q8IUS6
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Steroid Dehydrogenase Activity Endoplasmic Reticulum Endoplasmic Reticulum Organization Water Channel Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity	Regulation Of Intracellular Transport Positive Regulation Of Lipoprotein Transport Endomembrane System Glucose Import In Response To Insulin Stimulus Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Rough Endoplasmic Reticulum Membrane Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Lysophosphatidic Acid Acyltransferase Activity CDP-diacylglycerol Biosynthetic Process Vesicle Fusion To Plasma Membrane CDP-diacylglycerol Metabolic Process Endosome To Plasma Membrane Protein Transport Oxysterol Binding 1-acylglycerol-3-phosphate O-acyltransferase Activity D-glucose Import Regulation Of Skeletal Muscle Contraction Regulation Of Cellular Localization Positive Regulation Of Calcium Ion Import Phosphatidic Acid Biosynthetic Process D-glucose Transmembrane Transport Rough Endoplasmic Reticulum Phosphatidic Acid Metabolic Process Hexose Transmembrane Transport Regulation Of ATP-dependent Activity Regulation Of Cardiac Muscle Cell Contraction Sarcoplasmic Reticulum Membrane Carbohydrate Transmembrane Transport Regulation Of Calcium Ion Import
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