ADCY9 and NDRG4

Data Source: HiPPIP (Novel)

		ADCY9	NDRG4
Name		adenylate cyclase 9	NDRG family member 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cilium Membrane Axon Dendrite Ciliary Basal Body	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Cell Projection Membrane
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Protein Binding ATP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	In Utero Embryonic Development CAMP Biosynthetic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Heart Looping Signal Transduction Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	None
Drugs		Colforsin	None
GWAS		Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Body mass index ( 20935630 24861553 28448500 28552196 28892062 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index and fasting glucose (pairwise) ( 33619380 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Breast cancer ( 29058716 ) Breast cancer (estrogen-receptor negative) ( 29058716 ) Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Diverticular disease ( 30177863 ) Fasting glucose ( 34059833 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) Hand grip strength ( 29691431 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference ( 25673412 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Nonsyndromic cleft lip with or without cleft palate ( 25775280 ) Obesity ( 23563607 ) Partial epilepsies ( 20522523 ) Platelet count ( 32888494 ) Response to Dalcetrapib treatment in acute coronary syndrome ( 25583994 ) Systolic blood pressure ( 30578418 ) Thyroid stimulating hormone levels ( 32769997 30367059 ) Waist circumference ( 25673412 ) Weight ( 28552196 )	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) QT interval ( 19305408 19305409 22726844 ) Schizophrenia ( 29483656 )
Novel Interactors		1 novel interactors: NDRG4	5 novel interactors: ADCY9 ALDH6A1 CMTM3 DHX38 NOL3
Interacting Genes		1 interacting genes: HSPB1	37 interacting genes: AGTRAP APLNR ARFIP2 ARL6IP1 ATP5PF BCL2L13 CACFD1 CDR1 CIDEB CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A
Entrez ID		115	65009
HPRD ID		04489	14817
Ensembl ID		ENSG00000162104	ENSG00000103034
Uniprot IDs		O60503	A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Cell Projection Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Signal Transduction Protein Localization To Synapse Regulation Of Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Locomotion Positive Regulation Of Blood Vessel Endothelial Cell Migration Protein Folding Chaperone Protein Kinase C Binding Platelet Aggregation Axon Cytoplasm Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cell Communication Positive Regulation Of Interleukin-1 Beta Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Transport Anterograde Axonal Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cornified Envelope Protein Refolding Proteasome Complex Negative Regulation Of Signaling Homotypic Cell-cell Adhesion Visual Behavior Visual Learning Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Regulation Of Endocytic Recycling Embryonic Heart Tube Development Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Molecular_function Heart Looping Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Vesicle Docking Cell Migration Involved In Heart Development Embryonic Heart Tube Morphogenesis Positive Regulation Of Interleukin-1 Production Regulation Of Smooth Muscle Cell Migration Organelle Localization By Membrane Tethering Axo-dendritic Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Synaptic Vesicle Vesicle-mediated Transport Endoplasmic Reticulum Tubular Network Formation Cytoplasmic Vesicle Endoplasmic Reticulum Tubular Network Membrane Organization Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Priming Protein Binding Regulation Of Short-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Synaptic Vesicle Membrane Organization Endoplasmic Reticulum Membrane Organization