ADCY9

Name	adenylate cyclase 9
Structure	No pdb structure
Novel Interactors	1 novel interactors: NDRG4
Interactors	1 interactors: HSPB1
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cilium Membrane Axon Dendrite Ciliary Basal Body
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Protein Binding ATP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding
	Biological Process	In Utero Embryonic Development CAMP Biosynthetic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs	Colforsin
GWAS	Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Body mass index ( 20935630 24861553 28448500 28552196 28892062 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index and fasting glucose (pairwise) ( 33619380 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Breast cancer ( 29058716 ) Breast cancer (estrogen-receptor negative) ( 29058716 ) Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Diverticular disease ( 30177863 ) Fasting glucose ( 34059833 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) Hand grip strength ( 29691431 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference ( 25673412 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Nonsyndromic cleft lip with or without cleft palate ( 25775280 ) Obesity ( 23563607 ) Partial epilepsies ( 20522523 ) Platelet count ( 32888494 ) Response to Dalcetrapib treatment in acute coronary syndrome ( 25583994 ) Systolic blood pressure ( 30578418 ) Thyroid stimulating hormone levels ( 32769997 30367059 ) Waist circumference ( 25673412 ) Weight ( 28552196 )
Entrez ID	115
HPRD ID	04489
Ensembl ID	ENSG00000162104
Uniprot IDs	O60503
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Cell Projection Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Signal Transduction Protein Localization To Synapse Regulation Of Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Locomotion Positive Regulation Of Blood Vessel Endothelial Cell Migration Protein Folding Chaperone Protein Kinase C Binding Platelet Aggregation Axon Cytoplasm Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cell Communication Positive Regulation Of Interleukin-1 Beta Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Transport Anterograde Axonal Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cornified Envelope Protein Refolding Proteasome Complex Negative Regulation Of Signaling Homotypic Cell-cell Adhesion Visual Behavior Visual Learning Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Regulation Of Endocytic Recycling Embryonic Heart Tube Development Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Molecular_function Heart Looping Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Vesicle Docking Cell Migration Involved In Heart Development Embryonic Heart Tube Morphogenesis Positive Regulation Of Interleukin-1 Production Regulation Of Smooth Muscle Cell Migration Organelle Localization By Membrane Tethering Axo-dendritic Transport