TUBGCP5 and HEMK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TUBGCP5	HEMK1
Description		tubulin gamma complex component 5	HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Gamma-tubulin Complex Gamma-tubulin Ring Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cilium Ciliary Basal Body	Mitochondrion
	Molecular Function	Protein Binding Microtubule Binding Gamma-tubulin Binding Microtubule Minus-end Binding	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle	Translational Termination Methylation
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Obsessive-compulsive disorder ( 30456828) Triglyceride levels x loop diuretics use interaction ( 31806883)	Appendicular lean mass ( 33097823) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Height ( 28552196)
Interacting Genes		4 interacting genes: CLIC6 CRYAA HEMK1 TMEM132D	18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2
Entrez ID		114791	51409
HPRD ID		12177	13645
Ensembl ID		ENSG00000275835	ENSG00000114735
Uniprot IDs		Q96RT8	A0A140VK98 B2RA37 Q9Y5R4
PDB IDs		6L81 6V69 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VRD 8VRJ 8VRK
Enriched GO Terms of Interacting Partners?		Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding D2 Dopamine Receptor Binding N-methyltransferase Activity Lens Fiber Cell Morphogenesis Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Protein Methyltransferase Activity Translational Termination
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